Results 91 to 100 of about 6,489,129 (287)
Assessing responses and interventions to orphans and vulnerable children affected by HIV/AIDS: A case study of the experiences of HIV/AIDS orphans and vulnerable children in Gugulethu, Cape Town [PDF]
, 2010 Includes abstract.Includes bibliographical references (p. 69-77).This study examines how children who are exposed to the impact of HIV/AIDS in their immediate families are affected; what their experiences are and what coping strategies they employ on a ...
Seyuba, Mesele M
core +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Rethinking vulnerable groups in clinical research
, 2017 Vulnerable groups are often excluded from clinical research on the basis of scientific, ethical and practical reasons. Although intended to protect vulnerable people and maintain study integrity, exclusion of vulnerable groups from research through use ...
M. Finnegan, B. O’Donoghue
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Monkeypox infections in vulnerable groups
European Journal of Internal Medicine, 2023 Brendan Bryan Jen-Wei Tan +2 more
openaire +2 more sources
Targeting the Vulnerable and the Choice of Vulnerability Measures: Review and Application to Pakistan [PDF]
In this paper, the concept of vulnerability of the poor’s welfare and its practical measures are scrutinised in order to derive implications for targeting poverty reduction policies toward vulnerable households.
Takashi Kurosaki
core
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
The Inclusion of Vulnerable Groups in Slovenian Cultural Institutions
Social SciencesThe inclusion of vulnerable groups in cultural life is a central issue of social justice, equality, and sustainable development. While equality ensures formal access to cultural participation, equity requires differentiated, needs-responsive measures ...
Špela Pučko +2 more
doaj +1 more source
Identifying Economically Vulnerable Groups as the Economic Crisis Emerged [PDF]
A frequent refrain during recent debates on welfare cuts and tax increases has related to the need to “protect the vulnerable”. However, it is far from clear that a consensus exists on which individuals or groups are to be included under this heading ...
CHRISTOPHER T. WHELAN, BERTRAND MAITRE
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source