Results 61 to 70 of about 6,489,129 (287)

To what extent are vulnerability issues included and addressed in Kenya's health and immunization policy documents? A systematic review of documents [version 1; peer review: 2 approved]

NIHR Open Research
Introduction Globally, childhood immunization is one of the most important public health interventions contributing to a significant reduction in childhood mortality and morbidity.
Esther Awuor Owino, Dorcas Kamuya, David Mafigiri, Caroline Jones, Primus Chi   +4 more
doaj   +1 more source

The relative importance of aerobic capacity, physical activity and body mass index in impaired glucose toleranceand Type 2 diabetes [PDF]

, 2012
Aim: To investigate the relative importance of aerobic capacity, physical activity and body mass index (BMI) for discriminating between people with Impaired Glucose Tolerance (IGT) or Type 2 diabetes and healthy controls.
Svebak, Sven, Gundersen, Kjell Terje,, Hansen, Elisabeth, Svebak, Sven,, Landstad, Bodil Johanne, Gundersen, Kjell Terje, Landstad, Bodil Johanne,, Hansen, Elisabeth,   +7 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Social Distance from Vulnerable Groups. Perspectives from Students from Suceava County

International Journal of Social and Educational Innovation, 2018
The article aims to explore the social distance of high-school students towards certain vulnerable categories (people with disabilities, those of different religions, those without income, foreigners, refugees, Romani, people infected with HIV ...
Elena BUJOREAN
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Effectiveness Review: Promoting Sustainable Livelihoods for Women and Vulnerable Groups in Chiradzulu District, Malawi

, 2014
The aim of the 'Promoting Sustainable Livelihoods for Women and Vulnerable Groups' project, carried out in Chiradzulu District, Malawi, was to empower vulnerable people - especially women - through engagement in production and facilitating access to ...
Fuller, Robert
core   +1 more source

The white paper for vulnerable children [PDF]

, 2012
This White Paper sets out a framework which ensures key agencies and professionals working with children in New Zealand are better connected so they can share information on vulnerable children and identify their needs earlier.

core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source