Results 221 to 230 of about 33,525 (258)
Clinical and Experimental Dental Research, Volume 11, Issue 6, December 2025.ABSTRACT Background The bidirectional relationship between periodontitis and type 2 diabetes (T2D) underscores the need for adjunctive therapies to enhance nonsurgical periodontal therapy (NSPT). This meta‐analysis evaluates the efficacy of antioxidants in improving periodontal and glycemic outcomes in T2D patients with periodontitis.
Sara A. Abdulla +9 more
wiley +1 more source
Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12
Glia, Volume 73, Issue 12, Page 2464-2482, December 2025.Main Points Transcriptionally, P2RY12‐deficient microglia show heightened metabolic activity, iron handling and oxidative stress at baseline. Upon LPS challenge, impaired glutathione antioxidant responses suggest increased vulnerability to ferroptosis. ABSTRACT Microglia are the resident immune cells of the CNS.
Aida Oryza Lopez‐Ortiz +9 more
wiley +1 more source
Risk Factors for Cardiovascular and Metabolic Disease: Integrating Traditional and Novel Paradigms
iNew Medicine, Volume 1, Issue 1, December 2025.ABSTRACT Cardiovascular and metabolic diseases (CVMD), encompassing atherosclerotic cardiovascular disease (ASCVD), heart failure, obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD), remain the leading global cause of morbidity and mortality.
Zhihua Wang +3 more
wiley +1 more source
Alternative Splicing of SORBS1 Affects Neuromuscular Junction Integrity in Myotonic Dystrophy Type 1
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.ABSTRACT Background Myotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder characterized by CTG repeat expansion in the 3′ untranslated region of the dystrophia myotonica protein kinase coding gene. The presence of expanded CTG repeats in DMPK mRNAs leads to the sequestration of RNA‐binding factors such as the Muscleblind‐like (MBNL)
Caroline Hermitte +11 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.ABSTRACT Background Statins are cholesterol‐lowering drugs widely prescribed for preventing cardiovascular diseases. They may cause adverse effects on skeletal muscle, but it remains unclear whether they affect muscle function and mass. We aimed to evaluate the association between statin use and muscle function and mass, and whether the pharmacogenomic
Mélissa Gentreau +6 more
wiley +1 more source
Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions
MedComm, Volume 6, Issue 12, December 2025.A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu +4 more
wiley +1 more source
MedComm – Oncology, Volume 4, Issue 4, December 2025.Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan +7 more
wiley +1 more source
Brain iron distribution in transdiagnostic mental health burden
Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.Abstract Background Psychiatric diseases are increasingly understood as a spectrum or continuous phenomena, ranging from healthy to severely affected, yet neurobiological correlates for these dimensions remain elusive. Regional alteration of iron levels in the central nervous system may reflect neuropathological processes that result in significant ...
Rebecca Christina Coray +6 more
wiley +1 more source