Results 281 to 290 of about 76,465 (345)
ABSTRACT Objectives Oral health is an important aspect of quality of life for older people, especially those with dementia. The impact of an active oral hygiene program on the oral microbiome was explored in a group of older participants (average age 84 years old) with dementia against a separate control group whose oral hygiene followed the status quo.
Sangeeta Khadka+6 more
wiley +1 more source
Main Points Multiple sclerosis involves chronic CNS inflammation and neurodegeneration. This review highlights glial cells as key drivers in progressive MS, focusing on lesion pathology, molecular dysfunction, and human‐relevant model systems. ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by ...
Volker Siffrin
wiley +1 more source
Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota+4 more
wiley +1 more source
Assessment of coronary plaque vulnerability with intravascular ultrasound
Takafumi Hiro, Atsushi Hirayama
openalex +2 more sources
The Landscape of SPP1 + Macrophages Across Tissues and Diseases: A Comprehensive Review
SPP1+ macrophages represent a conserved, disease‐associated population present across cancerous and non‐cancerous conditions, involved in immunosuppression, fibrosis, lipid metabolism, phagocytosis, and other cellular processes. This review highlights their shared molecular programmes across tissues, their interactions with stromal and immune cells ...
Alessandro Palma
wiley +1 more source
Early childhood caries (ECC) involves cariogenic persisters that evade antimicrobial treatment. Persisters achieve this by downregulating heat shock proteins (HSPs) and formation of protein aggregates. Ti3C2 MXene‐based photothermal therapy (PTT) acts as a “nanothermal knife,” disrupting membranes, upregulating HSPs, inhibits aggregates, prevents ...
Yinyin Zhang+8 more
wiley +1 more source
Metabolic Programming Drives Protective and Inflammatory Monocyte Fates in Viral Encephalitis
Bone marrow monocytes infiltrate the West Nile virus‐infected brain and differentiate into HIF1‐α⁺ monocyte‐derived cells (MCs) that diverge into protective, antigen‐presenting or inflammatory, iNOS⁺ MCs with distinct metabolic programs and functions.
Claire L. Wishart+4 more
wiley +1 more source
Gelatinase and Vulnerability of Atherosclerotic Plaque
openaire +4 more sources
ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov+2 more
wiley +1 more source