Results 291 to 300 of about 76,465 (345)

Unraveling the complexity of neurodegeneration: heterogeneous damage patterns of locus coeruleus and substantia nigra in Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Alzheimer's disease (AD) involves complex neurodegeneration in the locus coeruleus (LC) and substantia nigra (SN), critical brain regions affecting cognitive and emotional processes. METHODS Using the National Alzheimer's Coordinating Center dataset of 11,583 participants, we conducted a multimodal analysis involving descriptive ...
Chao Tang   +6 more
wiley   +1 more source

Recent advances in neuroimaging of Alzheimer's disease and related dementias

open access: yesAlzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract This review covers recent advances (2023–2024) in neuroimaging research into the pathophysiology, progression, and treatment of Alzheimer's disease (AD) and related dementias (ADRD). Despite the rapid emergence of blood‐based biomarkers, neuroimaging continues to be a vital area of research in ADRD.
Julie Ottoy   +11 more
wiley   +1 more source

Midlife Steroid‐Binding Globulin Levels and In Vivo Neuroimaging Measures of Tau in Older Men and Women

open access: yesAnnals of Neurology, Volume 98, Issue 3, Page 524-532, September 2025.
Objective In men and women, sex steroid hormones have been associated with increased risk of Alzheimer's disease (AD) dementia. We aimed to investigate the influence of midlife testosterone and sex hormone binding globulin (SHBG) levels on later‐life in vivo markers of β‐amyloid (Aβ) and tau deposition in clinically healthy older men. Methods This time‐
Rachel F. Buckley   +16 more
wiley   +1 more source

Framework for assessing the risk to a field from fraudulent researchers: A case study of Alzheimer's disease

open access: yesJournal of the Association for Information Science and Technology, Volume 76, Issue 9, Page 1162-1173, September 2025.
Abstract Concerns over research integrity are rising, with increasing attention to potential threats from untrustworthy authors. We established a framework to gauge the potential negative influence of researchers potentially engaged in misconduct. The field of Alzheimer's disease (AD) research has been a focal point of these worries. This study aims to
Chaoqun Ni, B. Ian Hutchins
wiley   +1 more source

Shared Genetic Architecture Among Severe Mental Disorders: A System Biology Approach Based on Protein–Protein Interaction

open access: yesBrain and Behavior, Volume 15, Issue 9, September 2025.
This study explores the genetic overlap among PTSD, MDD, BD, and SZ, revealing shared biological pathways and co‐expression networks. Functional enrichment analysis highlights common molecular mechanisms underlying these psychiatric disorders, providing insights into their comorbidity and potential avenues for targeted therapeutic strategies.
Hernan F. Guillen‐Burgos   +8 more
wiley   +1 more source

Anti-JNK2 peptide–siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice [PDF]

open access: yes, 2018
Akk, Antonina   +11 more
core   +1 more source

Application of the Neuroform Atlas Stent for Intracranial Stenting of Symptomatic Intracranial Atherosclerotic Stenosis: A Multi‐Center Retrospective Study

open access: yesBrain and Behavior, Volume 15, Issue 9, September 2025.
Intracranial stenting with the Neuroform Atlas stent is a potentially safe and effective treatment for symptomatic intracranial atherosclerotic stenosis (sICAS). It demonstrates a statistically significant difference in the caliber of the target artery before and after treatment as well as significantly improves the cerebral ischemic symptoms of ...
Weicheng Peng   +9 more
wiley   +1 more source

From Tradition to Innovation: Acupuncture Therapies Targeting Ferroptosis in Neurological Disorders

open access: yesBrain and Behavior, Volume 15, Issue 9, September 2025.
• Ferroptosis drives cognitive decline in stroke and age‐related NDDs Iron‐dependent lipid peroxidation and oxidative stress trigger ferroptosis, a central mechanism underlying neuronal injury and cognitive deterioration in stroke and age‐related NDDs.
Haiyan Sun   +3 more
wiley   +1 more source

Management of Lost Atherectomy Devices in the Coronary Arteries

open access: yesCatheterization and Cardiovascular Interventions, Volume 106, Issue 3, Page 1766-1780, September 1, 2025.
ABSTRACT Rotational and orbital atherectomy are important tools to treat calcific coronary disease. Entrapment of an atherectomy device, that is, rotational atherectomy burr or orbital atherectomy crown, is a serious complication during atherectomy. Loss of an atherectomy device is a more challenging complication that usually follows device entrapment.
Gregor Leibundgut   +8 more
wiley   +1 more source

The structure, function, and distribution of gap junctions in the retina: Life cycle in health and disease

open access: yesJournal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
Gap junctions in healthy and diseases retina. Interneuronal gap junctions structured of connexin 36 and 45 present between retinal neurons provide passage for small molecules. Impaired conductivity of gap junctions participate in various retinal pathologies.
Anna Pacwa   +3 more
wiley   +1 more source

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