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This national analysis reveals rising mortality from peripheral circulatory complications in U.S. type 2 diabetes patients from 1999 to 2020, with stark disparities by race, gender, and geography. American Indian/Alaska Natives, males, and rural populations were disproportionately affected, highlighting the urgent need for targeted interventions ...
Iqra Shahid+12 more
wiley +1 more source
While cerebrovascular disease mortality in diabetics declined over two decades, the recent reversal highlights emerging challenges, possibly due to healthcare disruptions and socioeconomic disparities. These findings underscore the need for targeted public health interventions to address inequities and improve outcomes in high‐risk populations ...
Allahdad Khan+9 more
wiley +1 more source
Inflammation and plaque vulnerability [PDF]
AbstractAtherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs at sites of blood flow disturbance. The disease usually remains silent until a breakdown of integrity at the arterial surface triggers the formation of a thrombus.
Hansson, Goran, Libby, Peter, Tabas, Ira
exaly +5 more sources
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Seminars in Nuclear Medicine, 2023
Atherosclerotic plaques progress as a result of inflammation. Both invasive and noninvasive imaging techniques have been developed to identify and characterize plaque as vulnerable (more likely to rupture and cause a clinical event). Imaging techniques to identify vulnerable include identifying vessels with focal subendothelial collections of I ...
Takehiro Nakahara+3 more
openaire +2 more sources
Atherosclerotic plaques progress as a result of inflammation. Both invasive and noninvasive imaging techniques have been developed to identify and characterize plaque as vulnerable (more likely to rupture and cause a clinical event). Imaging techniques to identify vulnerable include identifying vessels with focal subendothelial collections of I ...
Takehiro Nakahara+3 more
openaire +2 more sources
Dyslipidemia and the vulnerable plaque
Progress in Cardiovascular Diseases, 2002In the last decade, an increasingly sophisticated understanding of the pathogenesis of atherosclerosis and its cardiovascular consequences has emerged. The characteristics of the unstable atherosclerotic plaque, the substrate for the majority of acute coronary events, have been well defined: mild-to-moderate stenosis, a lipid-rich pool, few smooth ...
John A. Farmer, Antonio M. Gotto
openaire +3 more sources
The Vulnerable Coronary Plaque
The Journal of Cardiovascular Nursing, 2000Vulnerable coronary plaques are asymptomatic atherosclerotic lesions with the tendency to rupture. Plaque rupture is the initiating event in most acute coronary syndromes including sudden cardiac death, acute myocardial infarction, and unstable angina. Vulnerable plaques are commonly found in coronary arteries at autopsy but are virtually undetectable ...
Ellen McErlean+2 more
openaire +3 more sources
Current Pharmaceutical Design, 2018
Background: Atherosclerosis is a systemic, progressive lipid-driven inflammatory disease of the arterial vascular wall leading progressively to plaque development. The vulnerable plaque, the one considered to be the leading cause of cardiovascular events seems to exhibit a large and soft lipid-rich necrotic core covered by a thin and inflamed fibrous
Maria Drakopoulou+3 more
openaire +3 more sources
Background: Atherosclerosis is a systemic, progressive lipid-driven inflammatory disease of the arterial vascular wall leading progressively to plaque development. The vulnerable plaque, the one considered to be the leading cause of cardiovascular events seems to exhibit a large and soft lipid-rich necrotic core covered by a thin and inflamed fibrous
Maria Drakopoulou+3 more
openaire +3 more sources
Neuroimaging Clinics of North America, 2005
The concept of vulnerable plaque is well established with increasing evidence from clinical and basic research. The paradigm has shifted from focusing exclusively on the hemodynamic effects of plaque (ie, resulting lumenal stenosis alone as a predictor of stroke risk) to assessment of the structure and composition of plaque (eg, denuded endothelium ...
Bruce A. Wasserman, John W. Chen
openaire +3 more sources
The concept of vulnerable plaque is well established with increasing evidence from clinical and basic research. The paradigm has shifted from focusing exclusively on the hemodynamic effects of plaque (ie, resulting lumenal stenosis alone as a predictor of stroke risk) to assessment of the structure and composition of plaque (eg, denuded endothelium ...
Bruce A. Wasserman, John W. Chen
openaire +3 more sources
From Vulnerable Plaque to Vulnerable Patient: The Search for Biomarkers of Plaque Destabilization
Trends in Cardiovascular Medicine, 2007There is a strong need for biomarkers to identify patients at risk for future cardiovascular events related with progressive atherosclerotic disease. Ideally, increasing knowledge of the mechanisms of atherosclerotic plaque destabilization should be translated in clinical practice. Currently, the following commonly followed strategies can be identified
Frans L. Moll+3 more
openaire +2 more sources