Results 301 to 310 of about 81,240 (338)
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Current Pharmaceutical Design, 2018
Background: Atherosclerosis is a systemic, progressive lipid-driven inflammatory disease of the arterial vascular wall leading progressively to plaque development. The vulnerable plaque, the one considered to be the leading cause of cardiovascular events seems to exhibit a large and soft lipid-rich necrotic core covered by a thin and inflamed fibrous
Maria, Drakopoulou +3 more
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Background: Atherosclerosis is a systemic, progressive lipid-driven inflammatory disease of the arterial vascular wall leading progressively to plaque development. The vulnerable plaque, the one considered to be the leading cause of cardiovascular events seems to exhibit a large and soft lipid-rich necrotic core covered by a thin and inflamed fibrous
Maria, Drakopoulou +3 more
openaire +2 more sources
Investigation of Atherosclerotic Plaque Vulnerability
2022Histochemical and immunohistochemical approaches permit the detection and evaluation of proteins and cell types within murine brachiocephalic artery atherosclerotic plaques, that can be subsequently analyzed to provide inferences on atherosclerotic plaque vulnerability.
George, Sarah J, Johnson, Jason L
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Inflammation and Plaque Vulnerability
Cardiovascular Drugs and Therapy, 2008Development of a thrombus at the site of an atherosclerotic plaque initiates abrupt arterial occlusion and is the proximate event responsible for the vast majority of acute ischemic syndromes. In nearly 75% of cases thrombus overlies a disrupted or ruptured plaque whereas the remainder of the thrombi overly an intact plaque with superficial endothelial
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Dyslipidemia and the vulnerable plaque
Progress in Cardiovascular Diseases, 2002In the last decade, an increasingly sophisticated understanding of the pathogenesis of atherosclerosis and its cardiovascular consequences has emerged. The characteristics of the unstable atherosclerotic plaque, the substrate for the majority of acute coronary events, have been well defined: mild-to-moderate stenosis, a lipid-rich pool, few smooth ...
John A, Farmer, Antonio M, Gotto
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Molecular Imaging of Vulnerable Plaque
Seminars in Nuclear Medicine, 2018Molecular imaging provides multiple imaging techniques to identify characteristics of vulnerable plaque including I) Inflammatory cells (the presence and metabolic activity of macrophages), II) synthesis of lipid and fatty acid in the plaque, III) the presence of hypoxia in severely inflamed lesions, IV) expression of factors stimulating angiogenesis ...
Takehiro, Nakahara +2 more
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2011
Beyond structural information obtained by traditional imaging modalities, molecular imaging can now visualize inflammation and proteolytic activity in the atheroma in-vivo. In addition, visualization of plaque neovascularization, and measurement of the plaque’s mechanical properties may enhance the identification of rupture-prone lesions. While limited
George D. Giannoglou +1 more
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Beyond structural information obtained by traditional imaging modalities, molecular imaging can now visualize inflammation and proteolytic activity in the atheroma in-vivo. In addition, visualization of plaque neovascularization, and measurement of the plaque’s mechanical properties may enhance the identification of rupture-prone lesions. While limited
George D. Giannoglou +1 more
openaire +1 more source
Randall’s plaque and calcium oxalate stone formation: role for immunity and inflammation
Nature Reviews Nephrology, 2021Saeed R Khan +2 more
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