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Inflammation and Plaque Vulnerability
Cardiovascular Drugs and Therapy, 2008Development of a thrombus at the site of an atherosclerotic plaque initiates abrupt arterial occlusion and is the proximate event responsible for the vast majority of acute ischemic syndromes. In nearly 75% of cases thrombus overlies a disrupted or ruptured plaque whereas the remainder of the thrombi overly an intact plaque with superficial endothelial
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From vulnerable plaque to atherothrombosis
Journal of Internal Medicine, 2008Abstract.Plaque rupture precipitates approximately 75% of all fatal coronary thrombi. Therefore, the plaque prone to rupture is the primary focus of this review. The lipid‐rich core and fibrous cap are pivotal in the understanding of plaque rupture.
Thim, T +3 more
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Vulnerable plaque: The biomechanics of matter
Atherosclerosis, 2014Despite the considerable progress that has been made in cardiology over the last four decades through intensive risk-factor modification and life-style changes, cardiovascular disease prevalence, morbidity andmortality remain high [1]. One coronary event occurs every 34 s leading to one death every 83 s in the United States [2].
Jolanda J. Wentzel +3 more
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Detection of Vulnerable Plaque
2019The use of optical coherence tomography (OCT) imaging in research and clinical practice has provided useful insights into the pathobiology of the “vulnerable plaque” and acute coronary syndromes (ACS). Although thin-cap fibroatheroma (TCFA), defined as a lipid-rich plaque covered by a thin (i.e.,
Vergallo R, Jang IK
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Molecular Imaging of Vulnerable Plaque
Seminars in Nuclear Medicine, 2018Molecular imaging provides multiple imaging techniques to identify characteristics of vulnerable plaque including I) Inflammatory cells (the presence and metabolic activity of macrophages), II) synthesis of lipid and fatty acid in the plaque, III) the presence of hypoxia in severely inflamed lesions, IV) expression of factors stimulating angiogenesis ...
Jagat Narula +5 more
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Thermal detection of vulnerable plaque
The American Journal of Cardiology, 2002In 1996, we showed that inflamed atherosclerotic plaques give off more heat and that vulnerable plaques may be detected by measuring their temperature. Plaque temperature is correlated directly with inflammatory cell density and inversely with the distance of the cell clusters from the luminal surface.
Ward Casscells +5 more
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Current Cardiovascular Imaging Reports, 2009
Atherosclerosis is a systemic inflammatory disease resulting in vascular complications such as myocardial infarction or stroke. Noninvasive imaging of early stages of this systemic disease could help guide early interventional or medical therapies.
Zur Mühlen, Constantin von +2 more
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Atherosclerosis is a systemic inflammatory disease resulting in vascular complications such as myocardial infarction or stroke. Noninvasive imaging of early stages of this systemic disease could help guide early interventional or medical therapies.
Zur Mühlen, Constantin von +2 more
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The vulnerable patient: Refocusing on the plaque?
Thrombosis and Haemostasis, 2009SummaryThe term ‘vulnerable plaque’ is used to refer to the lesions that are prone to rupture and may cause life-threatening events like acute coronary syndrome or stroke.The study of the vulnerable plaque phenotype and its detection has attracted increasing interest over the past decades.
Mat J.A.P. Daemen +2 more
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Identification of vulnerable atherosclerotic plaques
Expert Review of Cardiovascular Therapy, 2003There has been great interest in the possibility of identifying plaques that might be the site of future acute coronary events. These plaques are termed vulnerable and the majority are lipid-rich with an abundance of inflammatory cells and a thin fibrous cap.
Cezar S Staniloae, John A Ambrose
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Vulnerable Plaque: Detection and Management
Medical Clinics of North America, 2007Because most myocardial infarctions result from the rupture of a plaque that did not significantly compromise the coronary lumen before the event, experts widely accept that the morphology, composition, and degree of inflammation of a coronary atherosclerotic plaque is more important than the degree of luminal stenosis.
Dallit Mannheim +6 more
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