Results 171 to 180 of about 1,043,722 (370)

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Nanopore-Based Surveillance of Leishmania Parasites in Culicoides Latrielle (Diptera: Ceratopogonidae) Caught from the Affected Community and Tham Phra Cave in Chiang Rai Province, the Endemic Area of Leishmaniasis in Northern Thailand

Insects
In this research, we elucidated the species composition of Culicoides biting midges, infection prevalence, and genetic diversity of Leishmania parasites circulating in the affected community in Chiang Rai Province, being the most endemic area in Northern
Rinnara Ampol, Puckavadee Somwang, Pathamet Khositharattanakool, Chulaluk Promrangsee, Thanapat Pataradool, Piyapat Tepboonreung, Padet Siriyasatien, Kanok Preativatanyou   +7 more
doaj   +1 more source

SNAP use increased slightly in 2012 [PDF]

, 2013
This brief uses data from the American Community Survey to examine rates of Supplemental Nutrition Assistance Program (SNAP) receipt in 2012, track changes since the onset of the recession, and monitor receipt by region and place type.
Carson, Jessica A.
core   +1 more source

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

Advanced Science, EarlyView.
XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou   +15 more
wiley   +1 more source

The Proximity of High Volume Developmental Neurotoxin Polluters to Schools: Vulnerable Populations at Risk [PDF]

A substantial amount of environmental justice research has taken the form of “proximity studies” that analyze the race and class composition of populations living in close proximity to general sources of pollution.
Bruce London, Cristina Legot, John Shandra   +2 more
core  

Key Connectomes and Synaptic‐Compartment‐Specific Risk Genes Drive Pathological α‐Synuclein Spreading

Advanced Science, EarlyView.
Utilizing a stereotaxic injection mouse model and a novel mathematical approach, this study uncovers key subnetworks that drive pathological α‐synuclein (α‐Syn) progression in Parkinson's disease (PD). Remarkably, just 2% of the strongest connections in the connectome are sufficient to predict its spread.
Yuanxi Li, Justin Torok, Shujing Zhang, Jessica Ding, Ning Wang, Courtney Lau, Shruti Kulkarni, Chaitali Anand, Julie Tran, Michael Cheng, Claire Lo, Binbin Lu, Yanzi Sun, Robert Damoiseaux, Xia Yang, Ashish Raj, Chao Peng   +16 more
wiley   +1 more source

Financial incentives and vulnerable populations — will alternative payment models help or hurt? [PDF]

, 2018
Joynt Maddox, Karen E.
core   +2 more sources

Ramifications of State Budget Cuts to Human Services: Increases Jobs Loss, Decreases Economic Activity, Harms Vulnerable Populations [PDF]

, 2012
As Illinois struggles to recover from the worst recession in two generations, job growth and increased economic activity are of paramount concern to voters and lawmakers alike. The recent data make a clear and compelling case that cutting expenditures on
Amy Terpstra, Yerik Kaslow
core  

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

Creating a Spatial Vulnerability Index for Environmental Health [PDF]

arXiv
Extreme natural hazards are increasing in frequency and intensity. These natural changes in our environment, combined with man-made pollution, have substantial economic, social and health impacts globally. The impact of the environment on human health (environmental health) is becoming well understood in international research literature.
arxiv