Results 171 to 180 of about 365,962 (253)

Oral Health Status Among Children and Adolescents from Vulnerable Populations: A Cross-Sectional Study in Seville, Spain. [PDF]

Dent J (Basel)
Reyes-Lara RE, Curto A, Ribas-Perez D, Barbero-Navarro I, Rodriguez-Menacho D, Flores-Fraile J, Castaño-Séiquer A.   +6 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Social Determinants of Self-Reported Health in Vulnerable Populations During a Polycrisis in Lebanon.

JAMA Netw Open
Fayyad R, Ragi ME, Ghattas H, McCall SJ, Community Action for Equity in Pandemic Preparedness and Control (CAEP) Study Group.   +4 more
europepmc   +1 more source

Integrating psychiatry into a community based palliative care team for structurally vulnerable populations: a descriptive retrospective cohort study of the PEACH psychiatry program model. [PDF]

BMC Palliat Care
Thomas O, Sanon J, Thomson L, Dosani N, Rosenbaum D, Morey T.   +5 more
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Reducing patient waiting times in humanitarian settings: a data-driven approach to improving healthcare access for vulnerable populations. [PDF]

Arch Public Health
Alhawa EA, Presser E, Zahwe A, Faraj S, Al-Hajj S, Fares M, AlHalbi MF.   +6 more
europepmc   +1 more source

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine‐dependent Tumor Subset Under Metabolic Relationships With CAFs.

Advanced Science, EarlyView.
Researchers identified a pancreatic cancer subset with low global protein synthesis but heightened translation of stress‐response genes like ATF4, rendering cells resistant to chemotherapy and apoptosis. These tumors depend on serine and cysteine from surrounding cancer‐associated fibroblasts (CAFs), which shift to produce serine by curbing collagen ...
Sauyeun Shin, Mehdi Liauzun, Jacobo Solorzano, Morgane Le Bras, Christine Jean, Benjamin Fourneaux, Margaux Dore, Lea Fevrier, Ismahane Belhabib, Alexia Brunel, Cindy Neuzillet, Marion Larroque, Carine Joffre, Stephane Rocchi, Nicolas Fraunhoffer, Aurelie Perraud, Muriel Mathonnet, Vera Pancaldi, Laetitia Linares, Juan Iovanna, Nelson Dusetti, Ola Larsson, Remy Nicolle, Stephane Pyronnet, Corinne Bousquet, Yvan Martineau   +25 more
wiley   +1 more source

Profiling abuse and neglect of women with disabilities: a step towards prevention of mistreatment of vulnerable populations. [PDF]

Front Glob Womens Health
Savard J, Gavriilidis G, Lindblad A, Huang J, Zeitelhofer Adzemovic M.   +4 more
europepmc   +1 more source

SR‐B1‐Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis

Advanced Science, EarlyView.
This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang, Hailin Shang, Ling Jiao, Ce Chen, Zehua Liu, Yi Yang, Qiannan Zhang, Song Tang, Xudong Jia, Hui Yang, Yi Wan   +10 more
wiley   +1 more source

Diagnostic Testing Preferences in Rural and Vulnerable Populations During a Pandemic: Discrete Choice Experiment.

JMIR Public Health Surveill
van den Broek-Altenburg E, Benson J, Jonk Y, Leslie A, Carney J, Stein G.   +5 more
europepmc   +1 more source