Results 271 to 280 of about 8,761,625 (347)

Integrating psychiatry into a community based palliative care team for structurally vulnerable populations: a descriptive retrospective cohort study of the PEACH psychiatry program model. [PDF]

BMC Palliat Care
Thomas O, Sanon J, Thomson L, Dosani N, Rosenbaum D, Morey T.   +5 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Diagnostic Testing Preferences in Rural and Vulnerable Populations During a Pandemic: Discrete Choice Experiment.

JMIR Public Health Surveill
van den Broek-Altenburg E, Benson J, Jonk Y, Leslie A, Carney J, Stein G.   +5 more
europepmc   +1 more source

Profiling abuse and neglect of women with disabilities: a step towards prevention of mistreatment of vulnerable populations. [PDF]

Front Glob Womens Health
Savard J, Gavriilidis G, Lindblad A, Huang J, Zeitelhofer Adzemovic M.   +4 more
europepmc   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Inclusion of Women, Children, the Elderly, and Individuals With Underlying Medical Conditions: Prioritizing Vulnerable Populations in Clinical Research. [PDF]

Clin Infect Dis
Bruxvoort KJ, Bahakel H, Martin JM, Nayak JL, Rolsma SL, Healy CM, Creech CB.   +6 more
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Newly Diagnosed HIV in an Octogenarian Woman: A Case Report on Delayed Diagnosis in Vulnerable Populations. [PDF]

Clin Case Rep
Choi H, Chang MH, Choi H, Jeong W.
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Corrigendum to “Tobacco use behaviors and views on engaging in clinical trials for tobacco cessation among individuals who experience homelessness” [Contemporary Clinic. Trials Commun. 32 (2023) 101094]

Contemporary Clinical Trials Communications
Joshua Miller, Jordan Cuby, Sharon M. Hall, Maxine Stitzer, Margot Kushel, Donna Appiah, Maya Vijayaraghavan   +6 more
doaj   +1 more source