Results 311 to 320 of about 1,043,722 (370)

Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant Staphylococcus aureus

open access: yesAggregate, EarlyView.
A self‐assembling, aggregation‐enhanced tetrahedral DNA nanostructure (tFNA), termed TACs, enables localized accumulation and sustained release of ceftriaxone while co‐delivering antisense oligonucleotides that silence mecA, reduce PBP2a expression, and restore β‐lactam susceptibility in MRSA.
Yicheng Zhao   +10 more
wiley   +1 more source

Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils

open access: yesAggregate, EarlyView.
This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky   +3 more
wiley   +1 more source

Update on Omicron variant and its threat to vulnerable populations. [PDF]

open access: yesPublic Health Pract (Oxf)
Dai B   +5 more
europepmc   +1 more source

Smart Denture with Embedded Thin‐Film Temperature Sensors Patterned by Femtosecond Laser Pulse for Elderly Healthcare

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
We demonstrate the direct‐laser patterning of a gold thin film on polymethyl methacrylate to fabricate a temperature sensor for dentures. The temperature sensor‐embedded smart dentures are evaluated in an oral environment, enabling in‐situ monitoring for elderly healthcare.
Han Ku Nam   +7 more
wiley   +1 more source

Assessing Large Multimodal Models for One‐Shot Learning and Interpretability in Biomedical Image Classification

open access: yesAdvanced Intelligent Systems, EarlyView.
Image classification plays a pivotal role in biomedical image analysis. Herein, it is shown that large multimodal models, such as GPT‐4, achieve superior performance in one‐shot learning, generalization, interpretability, and text‐driven image classification. Applications span tissue, cell type, cellular state, and disease classification, outperforming
Wenpin Hou   +4 more
wiley   +1 more source

Sleep health inequities in vulnerable populations: Beyond sleep deserts. [PDF]

open access: yesSleep Med X
Al-Khalil Z   +5 more
europepmc   +1 more source

Artificial Intelligences: A Bridge Toward Diverse Intelligence and Humanity's Future

open access: yesAdvanced Intelligent Systems, EarlyView.
Many discussions of artificial intelligence fail to address deeper questions being raised by advances in developmental biology, neuroscience, bioengineering, and philosophy of mind. Novel beings, including technologically and biologically augmented humans, engineered life forms, hybrots, and others, require tools of the emerging field of diverse ...
Michael Levin
wiley   +1 more source

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