Results 31 to 40 of about 11,458 (262)

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Method to Assess and Enhance Vulnerable Road User Safety during Impact Loading

Applied Sciences, 2019
Every year approximately 1.35 million people die as a consequence of road accidents. Almost 50% of road fatalities are vulnerable road users (VRUs). This research reviews the history of traffic safety for VRUs, presents an interesting insight into the ...
Mariusz Ptak
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Evaluating the performance of a web-based vehicle blind zone estimation application: Validation and policy implications

Frontiers in Future Transportation, 2023
Pedestrian fatalities have been increasing in the United States over the past decade; in 2021 they reached a 40-year high and together with an increasing number of bicyclist fatalities surged to over 8,400 vulnerable road users (VRUs) killed by motor ...
Juwon Drake, Alessandra Vennema, Lily Slonim, Eric Englin, Alyssa Brodeur, Alexander K. Epstein, Donald L. Fisher   +6 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Urban traffic safety assessment: A case study of six Indian cities

IATSS Research, 2016
This study reports the results of fatal road traffic fatal crash data from six mid-sized cities in India: Agra, Amritsar, Bhopal, Ludhiana, Vadodara, and Vishakhapatnam.
Dinesh Mohan, Geetam Tiwari, Sudipto Mukherjee   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Blockchain-Based secure V2X communication for Privacy-Preserving vulnerable road user protections

Ain Shams Engineering Journal
Integrating Vulnerable Road Users (VRUs), such as pedestrians, cyclists, and motorcyclists, into Vehicle-to-Everything (V2X) networks enhances road safety, but it also creates significant security and privacy risks. Centralized Public Key Infrastructure (
Meshari D. Alanazi
doaj   +1 more source

Proposal of Risk Estimation Index from Driver Behaviour for Approaching and Overtaking Vulnerable Road User

International Journal of Automotive Engineering, 2022
To increase the acceptance and willingness of customers in using advanced driver assistance systems and autonomous vehicles, one of the best solutions is to reproduce the driving behavior of humans.
Manh-Dung Vu, Sueharu Nagiri, Hirofumi Aoki, Tatsuya Suzuki, Quy Hung Nguyen Van, Shouji Itou, Akira Hattori   +6 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source