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Chemotherapy of vulvar cancer: a review [PDF]

open access: possibleWiener klinische Wochenschrift, 2013
Squamous cell carcinoma of the vulva is a rare disease with good prognosis if diagnosed early. The standard primary therapy is surgery. Neoadjuvant radiation or chemotherapy has been used to achieve resectability of the tumor and to decrease the radicality of the surgery. Chemotherapy with platinum compounds, paclitaxel and targeted therapy (erlotinib)
Ira Winer   +3 more
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Invasive Cancer in the Vulvar Region

Acta Obstetricia et Gynecologica Scandinavica, 1982
Abstract. During the past 25 years there has been a tenfold increase in the incidence of vulvar cancer in Denmark. For this reason a material of 195 patients treated during the period 1960–77 is reviewed.There had been a considerable delay in treatment, due partly to the patients and partly to the doctor first seen.The five‐year survival rate was 63.3%
Benny Andreasson   +2 more
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Diet and the risk of vulvar cancer

Annals of Epidemiology, 1991
In this case-control study, 201 case patients with vulvar cancer and 342 community control subjects responded to a 61-item food frequency questionnaire. Risk was unrelated to intake of dark green vegetables, citrus fruits, legumes, and vitamins A and C and folate.
Regina G. Ziegler   +5 more
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Vulvar cancer metastatic to the breast

Gynecologic Oncology, 2006
Vulvar cancer rarely sends metastases to distant sites.A 49-year-old female presented with a vulvar mass. The histologic examination revealed an infiltrating lesion with free surgical margins and no evidence of lymph node involvement. Four months following surgery, due to a bloody breast discharge and a palpable breast lump an excisional biopsy was ...
Eitan Friedman   +4 more
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Systemic treatment of vulvar cancer

Expert Review of Anticancer Therapy, 2015
Squamous cell carcinoma of the vulva is a rare disease, accounting for approximately 5% of cancers of the female genital tract. Standard therapy for early-stage vulvar cancer mainly comprises of surgery of the vulva and groins. In locally advanced or metastatic vulvar cancer, neoadjuvant or definitive chemoradiation is often considered as an ...
Volkmar Mueller   +9 more
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Radio-Chemotherapy of Vulvar Cancer

Tumori Journal, 1998
Surgery alone, more or less demolitive, is the treatment of choice of vulvar cancers. Cure rates are high for early cancers only, while locally advanced tumors with or without inguinal adenopathies and recurrences have a bad prognosis. The excellent results of concurrent chemo-radiotherapy of anal cancers suggested to adopt the same approach for ...
Francesco Raspagliesi   +5 more
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Current Management of Vulvar Cancer

Hematology/Oncology Clinics of North America, 2012
1. Vulvar cancer is surgically staged. 2. Imaging such as CT of the abdomen and pelvis should be performed for women with tumors 2 cm or larger or to detect lymph node or other metastases. 3. Staging should include evaluation of factors related to prognosis: tumor size, depth of invasion, lymph node involvement, and presence of distant metastases.
Jonathan S. Berek, Katherine Fuh
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Margins for cervical and vulvar cancer

Journal of Surgical Oncology, 2016
Surgery is the primary treatment for vulvar cancer as well as early‐stage carcinoma of the cervix. This article reviews the significance of margin status after surgery on overall survival, need for further surgical intervention, and role for possible adjuvant therapy.
Mark Lachiewicz   +3 more
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Considerations for Vulvar Cancer

2017
Vulvar cancer is a rare malignancy of the female genital tract. Among other prognostic factors, numerous studies have highlighted that inguinofemoral lymph node status is the most important determinant of survival. Therefore, evaluation of the groins for possible metastases is an integral part of the surgical staging for these patients ...
Yukio Sonoda, Vasileios Sioulas
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Management of vulvar cancer

Cancer, 1995
Background. Current therapy of vulvar malignancies is reviewed with emphasis on screening, etiology, diagnosis, staging, and treatment of preinvasive and invasive cancer. Methods. Screening procedures, etiologic possibilities, diagnostic techniques, staging implications, and treatment approaches are discussed in detail. Results. All malignancies of the
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