Results 51 to 60 of about 7,629 (157)

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Advanced Science, Volume 12, Issue 44, November 27, 2025.
The artificial biosynthetic pathway potentially involved in biosynthesis of enfumafungin is first reconstructed in an optimized Aspergillus oryzae chassis with the increased site‐specific integration efficiency and shortened time for marker recycling, which requires an artificial fusion enzyme EfuA(TC)FsoA(GT).
Yaohui Gao, Jianming Lv, Yue Zhong, Zhiqin Cao, Rui Luo, Yue Qi, Gaoqian Wang, Shaoyang Li, Guodong Chen, Dan Hu, Hao Gao, Xinsheng Yao   +11 more
wiley   +1 more source

Developing the FIGO‐IPPS “R U MOVVING SOMe” classification system for female chronic pelvic pain

International Journal of Gynecology &Obstetrics, Volume 171, Issue 2, Page 550-565, November 2025.
Abstract The goal was to develop a pragmatic classification system for conditions associated with chronic pelvic pain (CPP), aiming to enhance diagnosis, management, education, and research of CPP. An international, multidisciplinary panel participated in a modified RAND/UCLA Delphi consensus.
Georgine Lamvu, Juan D. Villegas‐Echeverri, Catherine Allaire, Sawsan As‐Sanie, Jorge Carrillo, Susan Khalil, Andrew W. Horne, Alexander Wang, Malcolm G. Munro   +8 more
wiley   +1 more source

Antifungal Resistance of Candida spp. Isolates From HIV/AIDS Patients in Iran 1999–2024: A Systematic Review and Meta‐Analysis

Journal of Clinical Laboratory Analysis, Volume 39, Issue 21, November 2025.
Antimicrobial resistance in Candida spp. is significant in individuals with HIV/AIDS infections, particularly in Iran. In this systematic review, a comprehensive systematic search was conducted to identify all the eligible studies between 1999 and 2024; the pooled resistance rates of Candida spp. against antimicrobial agents were estimated. The risk of
Aliasghar Fakhri‐Demeshghieh, Ali Yousefipour, Yousef Bolouki, Mohammad Sadegh Bigdeli, Erfan Zamani, Amirreza Farajkhoda, Alireza Salmani, Farzad Katiraee, Saied Bokaie   +8 more
wiley   +1 more source

Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis [PDF]

Vestnik Dermatologii i Venerologii
The literature review presents modern aspects of the etiology and pathogenesis of vulvovaginal candidiasis, highlights issues of immunological resistance and the significance of polymorphic and pathological gene loci, the functioning of which leads to ...
Margarita R. Rakhmatulina, Elena V. Lipova, Viktoria A. Nyanenko   +2 more
doaj   +1 more source

Anaphylactic Shock Induced by Povidone‐Iodine Vaginal Irrigation During Pregnancy Complicated by Fetal Distress: A Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Anaphylaxis during pregnancy is common, but severe anaphylaxis during pregnancy is relatively rare and may have serious implications for both the mother and the fetus, potentially leading to maternal death or neonatal death. Anaphylaxis caused by iodophor skin disinfection is commonly observed, but there has been no reported case of severe ...
Yanmei Li, Shilin Zhong
wiley   +1 more source

Treatment of recurrent vulvovaginal candidiasis in women planning a pregnancy [PDF]

РМЖ. Мать и дитя, 2018
Treatment of recurrent vulvovaginal candidiasis in women planning a pregnancy Borovikov I.O., Kutsenko I.I., Gerasimenko E.E. Kuban State Medical University, Krasnodar Aim: evaluation of treatment methods for recurrent vulvovaginal candidiasis ...
Borovikov I.O., Kutsenko I.I., E.E. Gerasimenko   +2 more
doaj  

Abundant Yet Aberrant T Helper Cell Responses to Candida albicans Underlie Mucosal Candidiasis in Humans and Mice

European Journal of Immunology, Volume 55, Issue 10, October 2025.
Th17 cells confer protection against Candida albicans infection. In patients with STAT1 gain‐of‐function (GOF) mutations and chronic mucocutaneous candidiasis (CMC), Candida‐specific Th cell responses are numerically preserved but skewed toward Th1 and Th2.
Camilla Basso, Corinne De Gregorio, Roberta Marzi, Florian Kirchner, Gabor Gyülveszi, Mélanie Migaud, Sinu Paul, Alessandro Sette, Antonio Lanzavecchia, Salomé LeibundGut‐Landmann, Jean‐Laurent Casanova, Anne Puel, Simone Becattini, Federica Sallusto   +13 more
wiley   +1 more source

Nanozymes in Reactive Oxygen Species‐Dependent Diseases: From Design and Preclinical Studies to Clinical Translation Prospects

Small Structures, Volume 6, Issue 10, October 2025.
Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou, Jingyu Yan, Chenying Cui, Yurong Xu, Kaifang Zhang, Meijun Du, Zhuowei Zhang, Xiuping Wu, Bing Li   +8 more
wiley   +1 more source

Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology‐Driven Delivery Strategies

Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.
ABSTRACT This review highlights the integration of drug repurposing and nanotechnology‐driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application.
Dominique Mesquita e Silva, Laís de Souza Lacerda, Andrea de Souza Andrioli, Wilson Rodrigues Braz, Lara Melo Campos, Mayara Rodrigues Brandão de Paiva, Frederico Pittella, Rodrigo Luiz Fabri, Guilherme Diniz Tavares   +8 more
wiley   +1 more source

Ibrexafungerp: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 18, Issue 9, September 2025.
ABSTRACT Ibrexafungerp is a first‐in‐class triterpenoid antifungal that targets β‐(1,3)‐glucan synthase in fungal cell wall development. It is indicated for vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) in adult and post‐menarchal pediatric females.
Adelynne H. Walley, Lauren N. Dupuis, Erica L. Woodahl, Shayna R. Killam   +3 more
wiley   +1 more source