Results 71 to 80 of about 44,049 (242)

Genetic predisposition to a recurrent course of vulvovaginal candidiasis [PDF]

Гинекология, 2017
Vulvovaginal candidiasis (VVC) frequently occur in women of childbearing age. 5-10% of these women experience recurrent vulvovaginal candidiasis (RVVC), which is characterized by at least 4 episodes of infection in 12 months.
Sh M Pogosyan, E A Mezhevitinova, A E Donnikov, V N Prilepskaia, O V Burmenskaia, O S Nepsha, A A Bystritskiy   +6 more
doaj  

Efficacy and safety of oral ibrexafungerp for the treatment of acute vulvovaginal candidiasis: a global phase 3, randomised, placebo‐controlled superiority study (VANISH 306)

BJOG: an International Journal of Obstetrics and Gynaecology, 2021
To evaluate the efficacy and safety of ibrexafungerp versus placebo for acute vulvovaginal candidiasis (VVC) treatment.
Ryan H. Sobel, P. Nyirjesy, M. Ghannoum, Dimitar A Delchev, N. Azie, D. Angulo, I. A. Harriott, K. Borroto-Esoda, J. Sobel   +8 more
semanticscholar   +1 more source

Molecular Release by the Rotaxane and Pseudorotaxane Approach

Chemistry – A European Journal, Volume 31, Issue 23, April 22, 2025.
This review highlights the employment of rotaxane and pseudorotaxane architecture in the controlled release of target molecules both in solution and in the solid state. The properties conferred by the mechanical bond allow precise control over the release mechanism, thus leading to new forms of molecular cargo delivery when rotaxane‐based systems are ...
Raquel Peñaranda‐Navarro, Maria Collados‐Salmeron, Elena Carrilero‐Flores, Adrian Saura‐Sanmartin   +3 more
wiley   +1 more source

Development of an LC–MS/MS Method for Quantifying Occidiofungin in Rabbit Plasma

Journal of Mass Spectrometry, Volume 60, Issue 4, April 2025.
ABSTRACT Fungal infections are caused by opportunistic pathogens that can be life threatening and have been growing in prevalence. Many clinically relevant pathogens have resistance to or are developing resistance to the commonly used antifungal treatments.
Andrew Cothrell, Ravi S. Orugunty, Leif Smith   +2 more
wiley   +1 more source

Use of natamycin and ketoconazole suppositories in the treatment of recurrent vulvovaginal candidiasis [PDF]

РМЖ. Мать и дитя, 2018
Use of natamycin and ketoconazole suppositories in the treatment  of recurrent vulvovaginal candidiasis I.I. Ivanova1, Yu.E. Dobrokhotova2 1 Pirogov Russian National Research Medical University, Moscow, Russian Federation 2 Clinical ...
I.I. Ivanova, Yu.E. Dobrokhotova
doaj  

A Phase I, First‐In‐Human Study of CBA‐1205, an Anti‐DLK1 Monoclonal Antibody, in Patients With Advanced Solid Tumors

Cancer Science, Volume 116, Issue 4, Page 1012-1022, April 2025.
We conducted a Phase I trial of CBA‐1205, a novel monoclonal antibody targeting DLK1, in advanced solid tumors, demonstrating safety and tolerability with no dose‐limiting toxicities. Preliminary efficacy was observed, with six patients achieving stable disease for over 6 months, and sDLK1 was identified as a potential biomarker associated with ...
Yuki Katsuya, Masafumi Ikeda, Takafumi Koyama, Jun Sato, Mao Okada, Nobuaki Matsubara, Chihiro Kondoh, Toru Mukohara, Kazuo Watanabe, Daisuke Kotani, Yoshimi Ogawa, Shose Taoka, Noboru Yamamoto   +12 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study

Clinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Avner Sandhu, Tong Shen, Paz Martin Herrero, Chao‐Xing Yuan, Samirah Qureshi, Xiaoyu Jiang, Ye Sheng, Christoph Gasteyger, Yang Dai   +8 more
wiley   +1 more source

Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis [PDF]

Vestnik Dermatologii i Venerologii
The literature review presents modern aspects of the etiology and pathogenesis of vulvovaginal candidiasis, highlights issues of immunological resistance and the significance of polymorphic and pathological gene loci, the functioning of which leads to ...
Margarita R. Rakhmatulina, Elena V. Lipova, Viktoria A. Nyanenko   +2 more
doaj   +1 more source

Allergen‐Specific Immunotherapy and Trained Immunity

Allergy, Volume 80, Issue 3, Page 677-689, March 2025.
ABSTRACT The high prevalence of allergic diseases reached over the last years is attributed to the complex interplay of genetic factors, lifestyle changes, and environmental exposome. Allergen‐specific immunotherapy (AIT) is the single therapeutic strategy for allergic diseases with the potential capacity to modify the course of the disease.
Leticia Martín‐Cruz, Oscar Palomares
wiley   +1 more source

The Dermatology Life Quality Index (DLQI) used as the benchmark in validation of 101 quality‐of‐life instruments: A systematic review

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 3, Page 631-679, March 2025.
This study systematically analysed peer‐reviewed publications describing use of the DLQI in validation of other PRO and QoL measures and identified widespread use of the DLQI as a benchmark in validation of other dermatology PRO/QoL measures. It confirms the central role DLQI plays in the development of novel instruments and validation across ...
J. Vyas, J. R. Johns, Y. Abdelrazik, F. M. Ali, J. R. Ingram, S. Salek, A. Y. Finlay   +6 more
wiley   +1 more source