Results 31 to 40 of about 568,540 (291)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Rational antibacterial therapy for toxic osteonecrosis of the jaws [PDF]

Клиническая практика, 2020
Background. Toxic osteonecrosis of the jaw is a new disease of the XXI century. It develops due to the use of an artificially manufactured narcotic substance desomorphine. Aim.
G. I. Antakov, G. I. Shtraube, I. A. Boev   +2 more
doaj   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Nietzsche contra Schopenhauer? A reavaliação nietzschiana do valor metafísico da música

Revista de Filosofia Moderna e Contemporânea, 2016
O presente artigo explora as concepções schopenhaueriana e nietzschiana da música e as suas consequências para a reflexão filosófica de Schopenhauer e Nietzsche acerca desta arte.
Maria João Mayer Branco
doaj   +1 more source

Acute Endocrine Alterations After Traumatic Brain Injury and 6‐Month Functional Outcome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Acute multi‐axis endocrine alterations after traumatic brain injury (TBI) remain incompletely characterized. This study aimed to examine their temporal patterns and explore their associations with 6‐month functional outcome and early inflammatory markers.
Biao Xu, Peng Guo, Rui Pan, Zhenghao Wang, Jingchao Zhou, Pengcheng Zhang, Xingzhe Zhang, Qinghua Zhang, Haibin Ma, Zhanfeng Niu   +9 more
wiley   +1 more source

Contemporary Music and Its Challenges for Music Theory

Harmonia: Journal of Arts Research and Education, 2018
Contemporary music has found different ways in order to realize new methods of compositions in a process of indiviulazitation. Many of its phenomenons such as the abandonment of functional tonality have already been announced by composers such as Richard
Martin W. C. Link
doaj   +1 more source

The content and reporting completeness of physical therapist‐led interventions for glenohumeral osteoarthritis: a systematic review

Arthritis Care &Research, Accepted Article.
Objectives This study synthesised the content and reporting completeness of published physical therapist‐led interventions for glenohumeral osteoarthritis (GHOA). Methods This systematic review undertook electronic database searches in PubMed, EMBASE, Cochrane, CINAHL and PEDro (until June 2025) for any peer‐reviewed articles/studies describing ...
Daha G Muhammad, Nadine E Foster, Mickylle Pelaez, Karina O'Leary, Ilana N Ackerman, Jonathan G Quicke   +5 more
wiley   +1 more source

From Wagner to Metal Through Nietzsche: Dramatic Representation of Metal Music as Ritual, Sacrifice and Catharsis

Konservatoryum
The combined use of metal music, Wagner, and Nietzsche in the same context is rarely seen. Metal, as a modern musical style and subcultural movement, resonates with protest and musical distortion, while Wagner’s name is associated with opera and ...
Melis Mülazımoğlu
doaj   +1 more source

Resonancias tristanescas en la ópera española: Wagnerismo en las óperas de Conrado del Campo

Anuario Musical, 2010
La obra musical de Conrado del Campo, a pesar de su importancia e influencia en la música española de la primera mitad del siglo XX, permanece en un injusto olvido, especialmente su amplio legado operístico.
Víctor Sánchez Sánchez
doaj   +1 more source