Results 41 to 50 of about 1,209,855 (295)

Stochastic on-time arrival problem in transit networks

open access: yes, 2018
This article considers the stochastic on-time arrival problem in transit networks where both the travel time and the waiting time for transit services are stochastic.
Blandin, Sebastien   +2 more
core   +1 more source

Mapping the QCD Phase Transition with Accreting Compact Stars [PDF]

open access: yes, 2008
We discuss an idea for how accreting millisecond pulsars could contribute to the understanding of the QCD phase transition in the high-density nuclear matter equation of state (EoS). It is based on two ingredients, the first one being a ``phase diagram''
Alessandro Patruno   +10 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Adolescent trolling in online environments: a brief overview [PDF]

open access: yes, 2014
Over the last couple of years there has been increasing media coverage about trolling among teenagers. The term ‘troll’ appears to have originated from a method of fishing, where an individual would fish by trailing a baited line behind a boat.
Griffiths, MD
core  

Stationary Distribution Convergence of the Offered Waiting Processes for GI/GI/1+GI Queues in Heavy Traffic

open access: yes, 2019
A result of Ward and Glynn (2005) asserts that the sequence of scaled offered waiting time processes of the $GI/GI/1+GI$ queue converges weakly to a reflected Ornstein-Uhlenbeck process (ROU) in the positive real line, as the traffic intensity approaches
Lee, Chihoon   +2 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Building the War One Brick at a Time [PDF]

open access: yes, 2013
I\u27ve been waiting for this moment since 1996. Back then, when I was 11, My favorite toy came out with figures from my favorite era. The LEGO Western line was an amazing crossover of my love for history and my love for tiny ABS building blocks ...
Rudy, John M.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Data-Driven Simulation Modeling of the Checkout Process in Supermarkets: Insights for Decision Support in Retail Operations

open access: yesIEEE Access, 2020
We build a realistic agent-based model for simulating customer decisions of picking a checkout line at a supermarket that is calibrated to actual point of sale (POS) data from a major European retail chain.
Tomasz Antczak   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

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