Results 91 to 100 of about 11,519,954 (284)

Thermal Control of Concentric Topographies Patterned by Dynamic Electro‐Templated Generated Chiral Solitonic Structures

Advanced Science, EarlyView.
An electro‐templating strategy directs the relaxation of cholesteric finger loops into discrete concentric rings whose geometry is electrically programmed. The photopolymerized structures retain the topological defect pattern and, upon heating, show reversible, castle‐like surface modulation.
Jacques A. Peixoto, Hanqing Zhao, Dirk J. Broer, Ivan I. Smalyukh, Danqing Liu   +4 more
wiley   +1 more source

Competition and Waiting Times in Hospital Markets [PDF]

This paper studies the impact of hospital competition on waiting times. We use a Salop-type model, with hospitals that differ in (geographical) location and, potentially, waiting time, and two types of patients; high-benefit patients who choose between ...
Odd Rune Straume, Luigi Siciliani, Kurt R. Brekke   +2 more
core  

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Optimizing Bus Rapid Transit Systems: A Simulation Approach to Scheduling

Journal of Advanced Transportation
Driven by increasing urbanization and traffic congestion challenges, efficient and cost-effective public transportation solutions have become essential, positioning bus rapid transit (BRT) systems as an attractive alternative to conventional modes.
Safwan Altarazi, Nadia Janho
doaj   +1 more source

Waiting times and the decision to buy private health insurance. CHERE Working Paper 2010/9 [PDF]

Over 45% of Australians buy health insurance for private treatment in hospital. This is despite having access to universal and free public hospital treatment.
Elizabeth Savage, Meliyanni Johar, Michael Keane, Olena Stavrunova, Glenn Jones   +4 more
core  

Dipolar Coupling Errors in Nuclear Spin Qubits

Advanced Science, EarlyView.
Multi‐nuclear spin registers of phosphorus‐atom qubits in silicon have demonstrated 99.99% single and >$>$99.9% two qubit gate fidelities. Despite nanometer separation, read‐out fidelities between individual nuclear spins within the register are not identical.
I. D. Thorvaldson, P. Macha, J. Reiner, S. H. Misha, Y. Chung, L. Kranz, D. Keith, S. Monir, D. Poulos, S. Sutherland, Y.‐L. Hsueh, B. Thorgrimsson, R. Rahman, J. G. Keizer, S. K. Gorman, M. Y. Simmons   +15 more
wiley   +1 more source

The configuration, funding and costs of providing services for children with behaviours that challenge. [version 1; peer review: 1 approved, 2 approved with reservations]

NIHR Open Research
Background Children with intellectual disabilities and behaviours that challenge (BtC) and their families require complex, multi-agency support. Despite policy commitments to strengthen community-based provision, including those arising from Transforming
Stavros Petrou, Richard Hastings, Elizabeth-Ann Schroeder, Ashley Liew, Nicholas Manktelow, Caroline Richards, Mark Lovel, Nick Gore, Jill Bradshaw, Peter Langdon, Paul Thompson   +10 more
doaj   +1 more source

CD4+ T Cell Help Is Mandatory for Naive and Memory Donor-Specific Antibody Responses: Impact of Therapeutic Immunosuppression

Frontiers in Immunology, 2018
Antibody-mediated rejection is currently the leading cause of transplant failure. Prevailing dogma predicts that B cells differentiate into anti-donor-specific antibody (DSA)-producing plasma cells only with the help of CD4+ T cells.
Chien-Chia Chen, Chien-Chia Chen, Alice Koenig, Carole Saison, Carole Saison, Suzan Dahdal, Suzan Dahdal, Guillaume Rigault, Thomas Barba, Morgan Taillardet, Dimitri Chartoire, Michel Ovize, Michel Ovize, Emmanuel Morelon, Emmanuel Morelon, Emmanuel Morelon, Emmanuel Morelon, Thierry Defrance, Olivier Thaunat, Olivier Thaunat, Olivier Thaunat, Olivier Thaunat   +21 more
doaj   +1 more source

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, EarlyView.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, EarlyView.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source