Results 121 to 130 of about 649,618 (292)

2D Copper MOF Membranes with Precise Pores for Ionic Memory

Advanced Science, EarlyView.
 . ABSTRACT Biological ion channels play a critical role in the complex physiological processes of living organisms. Inspired by these natural systems, we demonstrate the fabrication of ultrathin 2D copper‐based metal‐organic framework (CuMOF) films and their application to mimic key functionalities of biological membranes. Using a liquid–air interface
Hiran Jyothilal, Raj Kumar Gogoi, Yuchen Liu, Vikas Sharma, Solleti Goutham, Michael Hutton, Rachel C. Kilbride, Daniel T.W. Toolan, Ashok Keerthi, Boya Radha   +9 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Exploratory analysis of associations between postpartum body condition changes measured by an automated 3-dimensional camera and reproductive outcomes measured by in-line milk progesterone analysis

JDS Communications
Our objective was to evaluate the associations of postpartum BCS changes, as predicted by automatic monitoring using 3-dimensional (3D) camera technology after calving, with milk yield and reproductive outcomes assessed both from in-line milk ...
Alessandro Frizza, Erminio Trevisi, Luca Cattaneo   +2 more
doaj   +1 more source

WAITING LINE METHOD DENGAN MODEL MULTI CHANNEL UNTUK EVALUASI PELAYANAN ADMINISTRASI

Jurnal Teknik Informatika STMIK Antar Bangsa, 2016
Abstract Evaluation is one of the important aspects needed to determine the success of a system. By doing evaluations can also be used for system development towards better. This study evaluates the existing system of administrative services to the campus BSI Cengkareng Waiting Line Method method. Queue is a regular occurrence in everyday life.
openaire   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Investigation of treatment delay in a complex healthcare process using physician insurance claims data: an application to symptomatic carotid artery stenosis

BMC Health Services Research
Background Delays in diagnostic and therapeutic processes are a potentially preventable cause of morbidity and mortality. Process improvement depends on accurate knowledge about as-is processes, historically collected from front-line workers and ...
Stephen Christopher van Gaal, Arshia Alimohammadi, Mohammad Ehsanul Karim, Wei Zhang, Jason Sutherland   +4 more
doaj   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Bilevel Optimization of Regular Bus-Subway-Shared Bicycle Cooperative Operation considering Dual Uncertainties

Journal of Advanced Transportation
The primary objective of this paper is to minimize the overall travel costs for passengers while simultaneously maximizing the operational revenue for the transportation company. This is achieved through the optimization and adjustment of various factors,
Yunqiang Xue, Tong He, Tao Li, Hongzhi Guan, Yang Qiu   +4 more
doaj   +1 more source

An Empirical Study of Waiting Line Optimization in Guarantee Trust Bank (Gtbank) Using Queuing Models

Financial Engineering
This study examines the waiting line system of Guaranty Trust Bank (GTB) using empirical queueing analysis to evaluate service efficiency, customer waiting costs, and the suitability of classical queueing assumptions. Primary data were collected from ATM terminals and the banking hall at (GTBank) in Ogbomoso, Nigeria, with interarrival and service ...
Oshuporu Opeoluwa Abosede, Adejumo Taiwo Joel, Oluwarohunbi Grace Olufunke, Titilola Adewale Abdulahi   +3 more
openaire   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source