Results 151 to 160 of about 193,514 (294)
Advanced Science, EarlyView.Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang +7 more
wiley +1 more source
Advanced Science, EarlyView.This study develops an iridium‐based nanozyme (IIN@M) with superior enzyme‐like activity and photothermal performance. It disrupts intracellular redox balance by generating reactive oxygen species and depleting glutathione, which synergistically induces ferroptosis, pyroptosis, and immunogenic cell death.
Lijun Ding +7 more
wiley +1 more source
Advanced Science, EarlyView.The HfxZr1‐xO2‐based ferroelectric/antiferroelectric bilayer capacitor exhibits morphotropic‐phase‐boundary behavior with a high dielectric constant (∼52) at 2 V. Phase engineering stabilizes o/t‐phase coexistence and suppresses m‐phase formation, enabling capacitance enhancement and self‐optimization under cycling for scalable low‐voltage, high‐κ ...
Junseok Kim +5 more
wiley +1 more source
Multimodal Layer‐Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes
Advanced Science, EarlyView.The study introduces a flexible microfluidic axialtrode that integrates optical, electrical, and chemical modalities within a single polymer fiber. By redistributing electrodes and fluidic channels along the fiber axis via angled cleaving, it enables simultaneous optogenetic stimulation, electrophysiological recording, and drug delivery across brain ...
Kunyang Sui +8 more
wiley +1 more source
DETECTION OF WAKEFULNESS DURING GENERAL ANAESTHESIA
British Journal of Anaesthesia, 1981 openaire +2 more sources
Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions
Advanced Science, EarlyView.This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao +4 more
wiley +1 more source
Advanced Science, EarlyView.Deuterated MOFs in this work exhibited unprecedented giant luminescence isotope effect via O─H oscillator suppression, achieving maximal solid‐state materials emission enhancement. This yields significantly improved X‐ray detection sensitivity and imaging resolution, marking the first integration of MOFs with isotopic luminescence and opening new ...
Junhao Lu +16 more
wiley +1 more source
Ship Wake Detectability in TerraSAR X Imagery – Summary and Applications for Wake Detection
, 2023 Tings, Björn +3 more
openaire +1 more source
Detecting wind turbine wakes with nacelle lidars:Paper
, 2017 Because the horizontal homogeneity assumption is violated in wakes flows, lidars face difficulties when reconstructing wind fields. Further, small-scale turbulence which is prevalent in wake flows causes Doppler spectrum widths to be broader than in the free stream. In this study the Doppler peak variance is used as a detection parameter for wakes.
Held, D. P., Larvol, A., Mann, Jakob
openaire +1 more source
Advanced Science, EarlyView.Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang +12 more
wiley +1 more source