Results 211 to 220 of about 132,762 (268)

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Nonpharmacological interventions to improve the sleep of informal caregivers of people with dementia: a systematic review and meta-analysis. [PDF]

Gerontologist
Wang S, Luo Y, Xiong J, Xia Y, Leung SHI, Davidson PM.   +5 more
europepmc   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Sleep Apnea and Paroxysmal Atrial Fibrillation: Diurnal Patterning of Autonomic Dysfunction and Influence of CPAP Therapy. [PDF]

J Arrhythm
Khazaie S, Wang L, Kaffashi F, Sandhu A, Chung MK, Heinzinger CM, Van Wagoner DR, Loparo KA, Walia HK, Bena JF, Mehra R.   +10 more
europepmc   +1 more source

Ketogenic interventions enhance REM sleep in females and support memory in aged rats. [PDF]

Front Aging Neurosci
Lark ARS, Mir FA, Ambareen N, Tian F, Carpenter AH, Crowley EA, Toro BA, Syme CE, Aygar S, Thendral A, Smith K, White CG, Mahamdeh MS, Choi J, Nehs CJ.   +14 more
europepmc   +1 more source

Couples Sharing Sleep and Sickness: Dyadic Sleep-Wake Patterns, Health Consequences, and Intervention Efficacy in Cancer Patient-Caregiver Dyads-A Systematic Review and Preliminary Meta-Analysis. [PDF]

Psychooncology
Zhong J, Liang W, Ho MH, Zhao W, Lin CC.
europepmc   +1 more source

Effects of adjunctive brexpiprazole with selective serotonin reuptake inhibitor treatment on anxiety and sleep architecture in mice. [PDF]

Int J Neuropsychopharmacol
Maruoka J, Kozuka K, Egami R, Kubo Y, Kakumoto Y, Kikuchi T, Kume K.   +6 more
europepmc   +1 more source

Post-stroke insomnia: multidimensional mechanisms, clinical heterogeneity, and toward mechanism-informed, objectively quantified management. [PDF]

Front Neurol
Liao J, Peng J, Wang Y, Wei Y, Wu J.
europepmc   +1 more source

Wake-promoting neuromodulators in Alzheimer's disease: Implications for sleep and brain clearance. [PDF]

Alzheimers Dement
Pedersen TJ, Clemens SG, Winer JR, Sharma A, Falgàs N, Lucey BP, Gordon BA, Musiek ES.   +7 more
europepmc   +1 more source