Results 61 to 70 of about 43,025 (262)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

A Study of the Near Wake Deformation of the X‐Rotor Vertical‐Axis Wind Turbine With Pitched Blades

Wind Energy
Recent studies have revealed the large potential of vertical‐axis wind turbines (VAWTs) for high‐energy‐density wind farms due to their favorable wake recovery characteristics. The present study provides an experimental demonstration and proof‐of‐concept
David Bensason, Andrea Sciacchitano, Adhyanth Giri Ajay, Carlos Simao Ferreira   +3 more
doaj   +1 more source

Intraoperative MEP and EMG during the wake-up phase as adjuncts to the wake-up test in severe spinal deformity surgery

Frontiers in Surgery
BackgroundThis study aimed to evaluate the adjunctive value of intraoperative motor evoked potential (MEP) recovery and electromyographic (EMG) activity during the wake-up phase in predicting postoperative neurological outcomes in high-risk patients with
Birong Gao, Yaolong Deng, Jian Chen, Juncheng Li, Jingfan Yang, Junlin Yang, Junlin Yang, Yaqing Zhang, Yaqing Zhang   +8 more
doaj   +1 more source

Miniaturized Bidirectional Thermal Stimulation System Integrated With an Electrode Array for Recording Neural Activities

Advanced Science, EarlyView.
This study presents a miniaturized bidirectional thermal stimulation system integrated with an electrode array enabling real‐time, bidirectional modulation and simultaneous recording of neural activity through localized heating and cooling. By monolithic integration of the Peltier element and with a silicon neural probe, the innovative system allows ...
Zoia Naumkina, Kanghwan Kim, Wesley Charles Smith, Keuntae Kim, Shinwoo Lee, Jiwan Woo, Il‐Joo Cho   +6 more
wiley   +1 more source

Monsoon‐Frontal Interactions Drive Cyclone Biparjoy's Wake Recovery in the Arabian Sea

Geophysical Research Letters
Cyclone‐generated cold wakes enhance productivity and impact local air‐sea interaction, paths and intensities of subsequent storms in the region. However, in‐situ observations of recovery across such wakes are rare.
Siddhant Kerhalkar, Ankitha Kannad, Alex Kinsella, Amit Tandon, Janet Sprintall, Craig M. Lee   +5 more
doaj   +1 more source

Wind turbine wake dynamics subjected to atmospheric gravity waves: a measurement-driven large-eddy simulation study [PDF]

Wind Energy Science
Atmospheric gravity waves (AGWs) are large-scale wave-like flow structures commonly generated when atmospheric flows are vertically perturbed by topographical features or meteorological phenomena.
D. Feng, D. Feng, N. Dangi, S. Watson
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Experimental Investigation of Wake Characteristics in Aligned and Staggered Wind Turbines

Energies
Wake interactions between wind turbines have a significant impact on the performance of downstream turbines and the overall efficiency of wind farms.
Bowen Yan, Haile Li, Tianhao Hong, Guowei Qian, Guoqing Huang   +4 more
doaj   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source