Results 211 to 220 of about 92,257 (361)

ENX‐101, a GABAA receptor α2,3,5‐selective positive allosteric modulator, displays antiseizure effects in rodent seizure and epilepsy models

Epilepsia, EarlyView.
Abstract Objective γ‐Aminobutyric acid type A (GABAA) receptor positive allosteric modulators (PAMs) that lack α‐subunit selectivity, including benzodiazepines such as diazepam, exhibit antiseizure actions in animal models and in humans. ENX‐101 is a deuterated analog of the ⍺2,3,5‐selective GABAA receptor PAM L‐838,417.
Jordi Serrats, Krishna C. Vadodaria, William Brubaker, Melissa Barker‐Haliski, H. Steve White, Alexis Evrard, Corinne Roucard, Eve Taylor, Kimberly E. Vanover, Stephen Cunningham, Vikram Sudarsan, Michael A. Rogawski   +11 more
wiley   +1 more source

Astrocytes at the heart of sleep: from genes to network dynamics. [PDF]

Cell Mol Life Sci
Bellier F, Walter A, Lecoin L, Chauveau F, Rouach N, Rancillac A.   +5 more
europepmc   +1 more source

Interictal Epileptic Spiking during Sleep and Wakefulness in Mesial Temporal Lobe Epilepsy: A Comparative Study of Scalp and Foramen Ovale Electrodes [PDF]

, 2003
Zsófia Clemens, József Janszky, Anna Szűcs, Mariann Békésy, Béla Clemens, Péter Halász   +5 more
openalex   +1 more source

Widespread decoupling of spindles and slow waves in temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Memory impairment is common in people with temporal lobe epilepsy (TLE). Recent studies in healthy subjects showed a positive correlation between sleep spindles coupled to slow waves (SWs) and memory performance. We aimed to determine differences in spindle–SW coupling in TLE patients compared to healthy controls using combined high ...
Katharina Schiller, Nicolás von Ellenrieder, Daniel Mansilla, Chifaou Abdallah, Kassem Jaber, Alfonso Garcia‐Asensi, John Thomas, Erica Minato, Jean Gotman, Birgit Frauscher   +9 more
wiley   +1 more source

25 years of <i>Drosophila</i> "Sleep genes". [PDF]

Fly (Austin)
Shafer OT.
europepmc   +1 more source

Orexin/Hypocretin: Wired for Wakefulness [PDF]

, 2003
Takatoshi Mochizuki, Thomas E. Scammell
openalex   +1 more source

Unique features of seizure‐induced cardiorespiratory failure in SSKcnj16−/− rats: Implications for sudden unexpected death in epilepsy

Epilepsia, EarlyView.
Abstract Objective Patients with uncontrolled epilepsy are at high risk for sudden unexpected death in epilepsy (SUDEP), which likely results from a pathological, seizure‐induced disruption of vital physiological systems. The objective of this study was to characterize seizure‐induced physiological dysfunction leading to death in SSKcnj16−/− rats and ...
Melissa Eilbes, Alexander Gallo, Wasif A. Osmani, Paloma Bittencourt‐Silva, Anna D. Manis, Matthew R. Hodges   +5 more
wiley   +1 more source

Acute Sleep Loss Increases Circulating Morning Levels of Two MicroRNAs Implicated in Neurodegenerative Disease in Healthy Young Men. [PDF]

J Cell Mol Med
Zhang L, Grip A, Hjelmqvist D, Benedict C, Brandão LEM, Cedernaes J.   +5 more
europepmc   +1 more source

Changes in Body Temperature and Sleep‐Wakefulness AfterIntrapreoptic Injection of Methoxamine in Rats [PDF]

, 2003
Ra. Vetrivelan, Hruda Nanda Mallick, Velayudhan Mohan Kumar   +2 more
openalex   +1 more source

Heartbeat-related activity in the anterior thalamus differs between phasic and tonic REM sleep. [PDF]

J Physiol
Simor P, Lilla RZ, Szalárdy O, Jordán Z, Halász L, Erőss L, Fabó D, Bódizs R.   +7 more
europepmc   +1 more source