Results 41 to 50 of about 55,386 (306)

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Neuronal avalanches change from wakefulness to deep sleep - a study of intracranial depth recordings in humans

, 2013
Neuronal dynamics differs between wakefulness and sleep stages, so does the cognitive state. In contrast, a single attractor state, called self-organized critical (SOC), has been proposed to govern human brain dynamics for its optimal information coding ...
Valderrama, Mario, Le Van Quyen, Michel, Priesemann, Viola, Wibral, Michael   +3 more
core   +1 more source

Measuring an Ongoing State of Wakefulness: The Development and Validation of the Inventory of Secular/Spiritual Wakefulness (WAKE) [PDF]

, 2023
Objectives: This study aimed to develop and validate a questionnaire assessing an ongoing state of wakefulness, a psychological state occurring in secular and spiritual contexts.
Marc Wittmann, Cynthia Bilodeau, Sebastian L. Kübel, Kübel, Sebastian, Wittmann, M, Wittmann, Marc, Bilodeau, C., Kilrea, K., Taylor, S, Linares Gutiérrez, D, Kelly A. Kilrea, Taylor, S., Linares Gutiérrez, D., Kübel, S., Kilrea, Kelly A., Wittmann, M., Bilodeau, Cynthia, Kübel, SL, Steve Taylor, Damisela Linares Gutiérrez, Kilrea, KA, Taylor, Steve, Gutiérrez, Damisela Linares, Bilodeau, C   +23 more
core   +1 more source

Medial Parabrachial Nucleus Is Essential in Controlling Wakefulness in Rats

Frontiers in Neuroscience, 2021
Activation of the parabrachial nucleus (PB) in the brainstem induced wakefulness in rats, suggesting which is an important nucleus that controls arousal. However, the sub-regions of PB in regulating sleep-wake cycle is still unclear.
Qi Xu, Qi Xu, Qi Xu, Dian-Ru Wang, Dian-Ru Wang, Hui Dong, Hui Dong, Li Chen, Li Chen, Jun Lu, Michael Lazarus, Yoan Cherasse, Gui-Hai Chen, Wei-Min Qu, Wei-Min Qu, Zhi-Li Huang, Zhi-Li Huang   +16 more
doaj   +1 more source

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Bottom-Up and Top-Down Mechanisms of General Anesthetics Modulate Different Dimensions of Consciousness

Frontiers in Neural Circuits, 2017
There has been controversy regarding the precise mechanisms of anesthetic-induced unconsciousness, with two salient approaches that have emerged within systems neuroscience.
George A. Mashour, George A. Mashour, George A. Mashour, Anthony G. Hudetz, Anthony G. Hudetz, Anthony G. Hudetz   +5 more
doaj   +1 more source

Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness?

Clocks & Sleep, 2021
The interpretation of the Maintenance Wakefulness Test (MWT) relies on sleep onset detection. However, microsleeps (MSs), i.e., brief periods of sleep intrusion during wakefulness, may occur before sleep onset.
Ludivine Des Champs de Boishebert, Pierre Pradat, Hélène Bastuji, François Ricordeau, Frédéric Gormand, Pierre Le Cam, Emeric Stauffer, Thierry Petitjean, Laure Peter-Derex   +8 more
doaj   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Ibogaine Acute Administration in Rats Promotes Wakefulness, Long-Lasting REM Sleep Suppression, and a Distinctive Motor Profile

Frontiers in Pharmacology, 2018
Ibogaine is a potent psychedelic alkaloid that has been the focus of intense research because of its intriguing anti-addictive properties. According to anecdotic reports, ibogaine has been originally classified as an oneirogenic psychedelic; i.e ...
Joaquín González, José P. Prieto, Paola Rodríguez, Matías Cavelli, Luciana Benedetto, Alejandra Mondino, Mariana Pazos, Gustavo Seoane, Ignacio Carrera, Cecilia Scorza, Pablo Torterolo   +10 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source