Results 161 to 170 of about 264,976 (250)

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Efficient Removal of Short‐Chain Perfluoroalkyl Substances by Cavity‐Directed Aggregation in a Molecular Cage Host

Angewandte Chemie, EarlyView.
A molecular cage exhibits strong entropy‐driven encapsulation of perfluoroalkyl substances (PFAS), accommodating up to four short‐chain guests as anionic aggregates. Guided by these molecular‐level insights, a novel host‐in‐host adsorbent is developed: mesoporous silica doped with 1 wt% cage achieves >98% removal of short‐ and long‐chain PFAS with full
Caroline V. I. Andersson, Sumali G. T. Mudiyanselage, Martin D. Peeks, Asja A. Kroeger, Jemma I. Virtue, Maximilian Mann, Justin M. Chalker, Michelle L. Coote, Martin R. Johnston, Witold M. Bloch   +9 more
wiley   +2 more sources

Life expectancy of people with intellectual disability: a retrospective cohort study from New South Wales, Australia. [PDF]

BMJ Open
Srasuebkul P, Trofimovs J, Trollor J.
europepmc   +1 more source

Alternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target

Annals of Neurology, EarlyView.
Objective Biallelic variants in PRKN cause autosomal recessive Parkinson's disease (PD) with a median age at onset of 31 years. When evaluating the 16 previously published carriers of a homozygous deletion of Exon 2 from the International Parkinson's Disease and Movement Disorder Society Gene Database (MDSGene) database, the median age at onset is ...
Arian Hach, Katja Lohmann, Manabu Funayama, Poornima J. Menon, Eva‐Juliane Vollstedt, Teresa Kleinz, Hiroyo Yoshino, Suzanne Lesage, Britta Meier, Carolyn M. Sue, Jean‐Christophe Corvol, Alexis Brice, Nobutaka Hattori, Christine Klein, Aleksandar Rakovic   +14 more
wiley   +1 more source

The Effect of Silk on the Stabilization of Labile Enzyme Lipoxygenase

Advanced NanoBiomed Research, EarlyView.
Entrapping lipoxygenase within silk significantly extended its stability from under 24 h to 10 days. Variations in silk molecular weight and freeze‐drying conditions influenced silk properties and enzyme interactions. This stabilization is leveraged to develop a linoleic acid electrochemical biosensor, integrating lipoxygenase with horseradish ...
Jacopo Giaretta, Xinyu (Vivian) Xie, Sandra Spoa, Hien A. Tran, Syamak Farajikhah, Sepehr Talebian, Jelena Rnjak‐Kovacina, Fariba Dehghani   +7 more
wiley   +1 more source

Emergency Department Syndromic Surveillance Diagnostic Code Selection for Assessing Severity of Seasonal Influenza in New South Wales, Australia. [PDF]

Influenza Other Respir Viruses
Rose N, Craig AT, Muscatello DJ.
europepmc   +1 more source

Miniaturized Conductometric Biosensor for Rapid Detection of TNF‐α in Saliva

Advanced NanoBiomed Research, EarlyView.
A miniaturized conductometric sensor detects TNF‐α at femtomolar levels with high selectivity. The device enables noninvasive testing using pooled human saliva and supports smartphone‐based, real‐time resistance readings. This portable biosensor offers a practical alternative for monitoring TNF‐α, providing new opportunities for diabetes and related ...
Mingjie Yang, Ying Zhi Cheong, Chenglong Xu, Sanje Mahasivam, Xudong Cai, Vipul Bansal, Sharath Sriram, Ganganath Perera, Madhu Bhaskaran   +8 more
wiley   +1 more source

Identifying subgroups with differential levels of service response to a digital screening and service navigation program for unmet social care needs. [PDF]

PLoS One
John JR, Winata T, Wang S, Smead M, Wu WT, Kohlhoff J, Schmied V, Jalaludin B, Lawson K, Liaw ST, Lingam R, Page A, Lam-Cassettari C, Boydell K, Lin PI, Katz I, Dadich A, Raman S, Grace R, Doyle AK, McClean T, Di Mento B, Preddy J, Woolfenden S, Eapen V.   +24 more
europepmc   +1 more source

Outpatient hospital attendances in people with rheumatoid arthritis during the COVID-19 pandemic and beyond: a cohort study in three nations of the UK. [PDF]

Rheumatology (Oxford)
Costello RE, Parker M, Kennedy J, Brophy S, Mehrkar A, Bacon S, Goldacre B, MacKenna B, Evans D, Tomlinson LA, Hollick RJ, Humphreys JH, OpenSAFELY Collective, The RHEUMAPS Study Investigators and the LH&W NCS (or CONVALESCENCE) Collaborative .   +13 more
europepmc   +1 more source

Assessing the viability of genebanked seeds from rare, wild plants native to the United States using the D.E.A.D. paradigm

Applications in Plant Sciences, EarlyView.
Abstract Premise Genebanks must maintain viable seeds for decades. Seeds that germinate are clearly alive, but some seeds, often from wild populations, do not germinate because they are dormant, empty, aged, or damaged (D.E.A.D.). This work evaluates the effects of D.E.A.D.
Christina Walters, Lisa M. Hill, Katherine D. Heineman, Hannah M. Tetreault, Shaimaa Ibrahim, Katherine Markstein, Cheryl Birker, Kris Freitag, Dustin Wolkis, Michael Kunz, Sheila Murray, Nathaniel Kingsley, Alexandra Seglias, Nicholas Matsumoto, Thomas N. Kaye, Cheryl Peterson, Matthew A. Albrecht, Noah Dell, Stacy Anderson, Steve Blackwell, David Remucal, Wendy Gibble, Anita Tiller, Emily Coffey, Jason Ligon, Laurie Blackmore, Carrie Radcliffe, Heather E. Schneider, Kristen Nelson, David Sollenberger, Jessamine Finch, Kate Wellspring, Robert Jetton, Joyce Maschinski   +33 more
wiley   +1 more source