Results 161 to 170 of about 645,067 (303)

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

Village of Norah, Land District of Gosford [cartographic material] /

, 1955
2nd ed. Cadastral town map of Norah, New South Wales, showing boundaries and landowners.; "Date of map 14th January, 1955."; Includes notes and tables.; "54.701."; Also available online http://nla.gov.au/nla.map ...
New South Wales. Department of Lands.
core  

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

Advanced Science, EarlyView.
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou, Kristine J. Fernandez, Min Li Huang, Ewan K. A. Millar, Claire Vennin, Leila Eshraghi, Tan Dat Timothy Lam, Victoria Lee, Nyah C. Brooks, Janett Stoehr, Cristian Guaman Mendez, Douglas Strathdee, David Stevenson, David Herrmann, Sandra O'Toole, Paul Timpson, Max Nobis, C. Elizabeth Caldon   +17 more
wiley   +1 more source

Arvine Wales letter to Arvine C. Wales, September 3, 1845

Arvine Wales mentions frost and warmer weather, local construction, geology and refers to mobs in Lexington, Ky that opposed the abolition of slavery.
Wales, Arvine
core  

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Interfacial Asymmetry and Surface Roughness Enhanced Topological‐Hall‐Like Transport in SRO/BTO/SRO Trilayers

Advanced Science, EarlyView.
Trilayer oxide architecture introduces interfacial asymmetry and surface roughness in SRO/BTO/SRO heterostructures, creating a locally modulated polar and magnetic landscape. This design enhances the topological‐Hall‐like response, achieving a broad 5–90 K stability window and a maximum ρTHE of 0.8 µΩ cm, demonstrating an effective route to amplify ...
Sagar E. Shirsath, Yunlong Sun, Xichao Zhang, Ji Zhang, Akash V. Fulari, Zizheng Song, Yee Yan Tay, Yin Yao, Zibin Chen, Sean Li, Xiaoxi Liu, Danyang Wang   +11 more
wiley   +1 more source

Quantifying the health and financial burden of adverse childhood experiences in Wales, England and English regions in 2023: a pooled analysis of 10 population surveys. [PDF]

BMJ Open
Hughes K, Ford K, Bellis MA, Quigg Z, Hopkins JC.   +4 more
europepmc   +1 more source

Parish of Myall, County of Arrawatta [cartographic material] : Land District of Inverell, Ashford Shire, Eastern Division N.S.W /

, 1947
6th ed. Cadastral map of the Parish of Myall, New South Wales showing parish boundaries and land holdings. Relief shown by hachures.; "Date of map, 8th July 1947.".; "67-542".; Includes tables and notes.; Also available online http://nla.gov.au/nla.map ...
New South Wales. Department of Lands.
core  

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Sliding Ferroelectric Metals: An Emerging Frontier

Advanced Science, EarlyView.
This Perspective highlights recent advances in sliding ferroelectric metals, focusing on the coexistence of switchable polarization and metallicity. Representative nonmagnetic and magnetic systems are discussed, together with Berry‐curvature memory, superconducting switching, triply‐coupled switching, magnetoelectric coupling, and electrically ...
Ying Yang, Zhenzhou Guo, Xia Cheng, Xiaotian Wang   +3 more
wiley   +1 more source