Results 191 to 200 of about 8,102 (257)

Geographic Variation in Loneliness and Social Isolation in Australia: Socio-Demographic and Healthcare Utilisation Determinants. [PDF]

Healthcare (Basel)
Earnest A, Lim MH, Engel L, Filia K, Clifford S, Rizal F, Hayes L, Zoungas S, Pourghaderi A, Nejati H, Berk M, Le LK, Skouteris H, Mihalopoulos C.   +13 more
europepmc   +1 more source

CREAT: A CRISPR‐Based Genome Trimming Strategy for Systematic Identification of Dispensable Regions and Rapid Genome Reduction

Advanced Science, EarlyView.
Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan, Zhe Gao, Yingxuan Qi, Yang Zhang, Xuhui Tian, Pengpeng Zhao, Xu Feng, Qunxin She   +7 more
wiley   +1 more source

The role of residential urban form and built environment in supporting social interaction, health, and well-being: a focus on forming and maintaining ties. [PDF]

Int J Health Geogr
Ishikawa T, Kyttä M, Rinne T.
europepmc   +1 more source

The era of walkability

The Japanese Journal of Real Estate Sciences, 2019
openaire   +2 more sources

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Identifying Co-occurring Neighbourhood Environmental Patterns and Their Association with Health Behaviours in a Dutch Urban Population at High Cardiometabolic Risk

Smit AK, Vos RC, Velde LAvd, Haas MR, Numans ME, Beenackers MA, Bonten TN, Jong JCK.   +7 more
europepmc   +1 more source

Walking environments for aging communities in municipality regions in China: measuring physical function toward population health challenges. [PDF]

Front Public Health
Wei S, Yu H, Sun C.
europepmc   +1 more source

Built environment and the evolution of cardiometabolic risk factors: a systematic review and meta-analysis of longitudinal studies. [PDF]

BMC Med
Feyissa TR, Beks H, Tolossa T, Wood SM, Mc Namara K, Versace VL, Coffee NT, Schroers RD, Alsharrah S, Daniel M.   +9 more
europepmc   +1 more source

A cross-sectional analysis of disparities in neighborhood physical activity environments across the urban-rural Spectrum in the contiguous United States. [PDF]

Prev Med
Xiong N, Wan N, Wen M.
europepmc   +1 more source