Results 21 to 30 of about 463,388 (260)

Design and Evaluation of a Wearable Powered Foot Orthosis with Metatarsophalangeal Joint

Applied Bionics and Biomechanics, 2018
The metatarsophalangeal (MTP) joints play critical roles in human locomotion. Functional restriction or loss of MTP joints will lead to lower walking speed, poorer walking balance, and more consumed metabolic energy cost compared with normal walking ...
Yixiang Liu, Xizhe Zang, Niansong Zhang, Ming Wu   +3 more
doaj   +1 more source

Pilgrimage as a Medium: Teaching Art on the Camino de Santiago

Ad Limina
Walking as a social art practice is a pedagogical tool for teaching pilgrimage, allowing students to map their experiences onto a millennia-old tradition while forming a dialogue with the expansive surrounding landscape.
Roxana Pérez-Méndez , Mario Marzan
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Simplifying rehabilitation control of lower-limb exoskeletons in five ambulation modes via dataset-driven state-machine calibration

Journal of NeuroEngineering and Rehabilitation
Background Lower-limb exoskeletons are a useful tool in rehabilitation settings as they can provide customized assistance to individuals during functional exercises.
Clément Lhoste, Alberto Cantón, Emek Barış Küçüktabak, Matthew R. Short, Rebecca Schwanemann, Shoshana Clark, Daniel Ludvig, Kevin Lynch, Levi Hargrove, Jesús Tornero, Lorenzo Vianello, José Pons   +11 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Extraordinary abilities, creativity, and love, in the path of dementia: a perspective article on the Walking the Talk for Dementia 2025 initiative

Frontiers in Dementia
This manuscript, co-created by researchers and people living with dementia and their care partners, explores how engagement with lived experience can transform conventional, deficit-based understandings of dementia—often defined by what is lost.
Madalena P. Liougas, Madalena P. Liougas, Prabha Shrestha, Prabha Shrestha, Belen Custodio, Lenisa Brandao, Kevin Cullen, Kevin Cullen, Therese Maher, Karen Young, Alan Young   +10 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source