Results 201 to 210 of about 2,027,729 (286)

Lactate Homeostasis Disruption Potentiates TACE‐Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Lactate homeostasis is disrupted through spatially coordinated extracellular neutralization and intracellular acidification, triggering calcium overload, mitochondrial dysfunction, and immunogenic cell death. This metabolic reprogramming alleviates the immunosuppressive tumor microenvironment and enhances immune checkpoint blockade, providing a ...
Minjiang Chen, Xiaoxiao Chen, Baozhu Yang, Hui Xu, Xueting Sun, Hongkai Qi, Huilin Hu, Ronghua Wu, Fengkai Qiu, Bing Wu, Yu Luo, Gaofeng Shu, Jiansong Ji   +12 more
wiley   +1 more source

Clinical, Radiological, and Endoscopic Features of Pancreatic Pseudocyst and Walled-Off Necrosis: How to Diagnose and How to Drain Them. [PDF]

J Clin Med
Dell'Anna G, Lavalle S, Biamonte P, Fanizza J, Masiello E, Bruni A, Mandarino FV, Preatoni P, Azzolini F, Dhar J, Samanta J, Facciorusso A, Stasi E, Brigida M, Dell'Anna A, Spampinato M, Maida M, Massironi S, Annese V, Fuccio L, Donatelli G, Danese S.   +21 more
europepmc   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Acute pancreatitis after total aortic arch replacement leading to walled-off necrosis: A case report and review of literature. [PDF]

World J Clin Cases
Inoue Y, Yata Y, Yokota Y, Li ZL, Kawabata K.   +4 more
europepmc   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Enhancing visibility and hemostasis during necrosectomy for walled-off necrosis: the "dual-gel method". [PDF]

Endoscopy
Hama K, Toyonaga H, Ishii T, Motoya M, Kin T, Hayashi T, Katanuma A.   +6 more
europepmc   +1 more source

Agronomic and Nutritional Perspectives on Vegetable Crops in Africa

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Vegetable production plays a key role in food security, nutrition, and livelihoods across Africa. Moreover, African indigenous vegetables emerge as underutilized yet highly valuable crops, rich in macro‐ and micronutrients, as well as bioactive compounds with an array of health benefits.
Đorđe Vojnović, Pamela Owusu Osei, Sina Siavash Moghaddam, Issiake Konate, Jelena Popović‐Đorđević   +4 more
wiley   +1 more source

Exploring lumen-apposing metal stents as a novel approach for managing walled-off necrosis in pediatric acute pancreatitis in Indian cohort: a prospective study. [PDF]

Clin Endosc
Mehta V, Abhinav A, Gupta YK, Khubber M, Sood A, Goyal MK.   +5 more
europepmc   +1 more source

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita, Tadanobu Shimura, Mikio Kawamura, Yuhki Koike, Yuji Toiyama   +4 more
wiley   +1 more source

Novel grasp-and-snare technique for efficient endoscopic necrosectomy of walled-off necrosis. [PDF]

Endoscopy
Toyonaga H, Hayashi T, Hama K, Kin T, Motoya M, Takahashi K, Katanuma A.   +6 more
europepmc   +1 more source