Results 51 to 60 of about 250,968 (293)

Student Perception of the Integrated PBL MBCHB-III Program Curriculum in a Medical University

Canadian Medical Education Journal, 2011
Introduction: Integrated PBL is now an accepted method of teaching the medical curriculum. The objective of this study was to determine MBChB-III students’ perceptions about some key aspects related to our integrated PBL curriculum. Methods: This was an
Mirta Garcia-Jardon, Vivek G Bhat, Ernesto Blanco-Blanco, Enoch Kwizera   +3 more
doaj  

Drivers of insect herbivory resistance and tolerance to plant damage in the Brachypodium distachyon species complex

American Journal of Botany, EarlyView.
Abstract Premise Insect herbivory is a major biotic factor shaping plant populations and driving the evolution of defensive traits. Polyploidy (whole‐genome duplication) often induces substantial phenotypic and genotypic changes that may affect species interactions, including herbivory.
Antonio J. Manzaneda, Luisa M. Martínez, Ana Fernández‐Ocaña, Teresa Salido, Pedro J. Rey   +4 more
wiley   +1 more source

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID

Nature Communications
The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has highlighted the vulnerability of a globally connected population to zoonotic viruses. The FDA-approved coronavirus antiviral Paxlovid targets the essential SARS-CoV-2 main protease, Mpro ...
Stefanie M. Bader, Dale J. Calleja, Shane M. Devine, Nathan W. Kuchel, Bernadine G. C. Lu, Xinyu Wu, Richard W. Birkinshaw, Reet Bhandari, Katie Loi, Rohan Volpe, Yelena Khakham, Amanda E. Au, Timothy R. Blackmore, Liana Mackiewicz, Merle Dayton, Jan Schaefer, Lena Scherer, Angus T. Stock, James P. Cooney, Kael Schoffer, Ana Maluenda, Elizabeth A. Kleeman, Kathryn C. Davidson, Cody C. Allison, Gregor Ebert, Gong Chen, Kasiram Katneni, Theresa A. Klemm, Ueli Nachbur, Smitha Rose Georgy, Peter E. Czabotar, Anthony J. Hannan, Tracy L. Putoczki, Maria Tanzer, Marc Pellegrini, Bernhard C. Lechtenberg, Susan A. Charman, Melissa J. Call, Jeffrey P. Mitchell, Kym N. Lowes, Guillaume Lessene, Marcel Doerflinger, David Komander   +42 more
doaj   +1 more source

Factors influencing implementing inclusive education in Chris Hani East district, South Africa

International Journal of Studies in Inclusive Education
This paper investigates how inadequate teacher training can influence the implementation of inclusive education. It explores how insufficient preparation in inclusive pedagogy, differentiated instruction, and identification of diverse learning needs ...
Thanduxolo Nomtshongwana, Manyakaza Aviwe, Buka Andria Mqondiso   +2 more
doaj   +1 more source

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Nature Communications, 2018
BAX and BAK are pro-apoptotic proteins whose activity is essential for the action of many anti-cancer drugs and to suppress tumorigenesis. Here, the authors perform a genome-wide CRISPR/Cas9 screen and identify VDAC2 as a promoter of BAX-mediated ...
Hui San Chin, Mark X. Li, Iris K. L. Tan, Robert L. Ninnis, Boris Reljic, Kristen Scicluna, Laura F. Dagley, Jarrod J. Sandow, Gemma L. Kelly, Andre L. Samson, Stephane Chappaz, Seong L. Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M. Hall, Andrew J. Kueh, Michael T. Ryan, Ruth M. Kluck, Philippe Bouillet, Marco J. Herold, Daniel H. D. Gray, David C. S. Huang, Mark F. van Delft, Grant Dewson   +26 more
doaj   +1 more source

Walter F. Dillingham, letter, 1932-12-23, to Hamlin Garland

, 2021
Unknown
openalex   +1 more source

Low‐Temperature Reverse Water–Gas Shift Enabled by Magnetically Induced Catalysis

Angewandte Chemie, EarlyView.
Magnetically induced catalysis using standard Cu–Al spinel‐derived catalyst functionalized with carbon‐coated iron nanoparticles enables high CO yield (up to 62%) at mild catalyst and reactor temperatures (estimated at 300°C and determined as 25–123°C, respectively).
Junhui Hu, Lise Marie Lacroix, Jacob Johny, Sourav Ghosh, Elisabeth Hannah Wolf, Jeongmin Ji, Sheng‐Hsiang Lin, Manisha Durai, Alin Benice Schöne, Walid Hetaba, Holger Ruland, Walter Leitner, Alexis Bordet   +12 more
wiley   +2 more sources

Self-Adjuvanting Bacterial Vectors Expressing Pre-Erythrocytic Antigens Induce Sterile Protection against Malaria

Frontiers in Immunology, 2013
Genetically inactivated, Gram-negative bacteria that express malaria vaccine candidates represent a promising novel self-adjuvanting vaccine approach. Antigens expressed on particulate bacterial carriers not only target directly to antigen-presenting ...
Elke eBergmann-Leitner, Heather eHosie, Jessica eWhittington, Elizabeth eDeRiso, Ryan eRanallo, Timothy eAlefantis, Tatyana eSavranskaya, Paul eGrewal, Christian eOckenhouse, Malabi eVenkatesan, Vito eDelVecchio, Evelina eAngov   +11 more
doaj   +1 more source

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

Residue‐Specific Signatures of Structural Water Identified by Dissolution Dynamic Nuclear Polarization with UV‐Generated Radicals

Angewandte Chemie, EarlyView.
Structural water molecules in proteins are notoriously hard to detect in solution. Hyperpolarized water with UV radicals as polarizing agents provides the sensitivity and resolution to detect residue‐specific signatures of structural water with NMR spectroscopy.
Fabian Hecker, Kaare Teilum, Andrea Capozzi, Mathilde Hauge Lerche   +3 more
wiley   +2 more sources