Results 231 to 240 of about 8,292 (286)

Inulin‐Butyrate Nanogel for Modulation of Gut Microbiome, Intestinal Barrier, and Regulatory T‐Cells in Colitis

open access: yesSmall, EarlyView.
IBD is driven by a vicious cycle of dysbiosis, barrier dysfunction, and immune dysregulation. We developed an inulin–butyrate conjugate nanogel (IBN) that accumulates in inflamed colon and releases butyrate via microbial inulinase/esterase. The inulin shell remodels the microbiome, while localized butyrate strengthens barrier integrity and promotes ...
Nayoon Park   +7 more
wiley   +1 more source

Immune escape mechanisms revealed by multifunctional nanoprobes targeting PD‐L1 in hepatic cancer progression

open access: yesVIEW, EarlyView.
The ICGB@Apt nanoprobes are designed to specifically recognize immune checkpoint molecules such as PD‐L1, thereby enabling precise monitoring of the progression from liver cirrhosis to HC. By binding to PD‐L1 on tumor cells, ICGB@Apt visualizes immune escape events and tumor metastasis while simultaneously reflecting the dynamic interaction between ...
Yiteng Meng   +5 more
wiley   +1 more source

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy

open access: yesVIEW, EarlyView.
Nectin‐4 is frequently overexpressed in solid tumors, yet many PDT photosensitizers show poor water solubility and nonspecific uptake. A Nectin‐4‐targeted nanobody–chlorin e6 conjugate (NPC) improves aqueous solubility and selectively accumulates in Nectin‐4‐positive tumor cells.
Haodian Wan   +10 more
wiley   +1 more source

Gastric volvulus and splenopancreatic torsion with wandering spleen: A case report. [PDF]

open access: yesInt J Surg Case Rep
Belayneh ES   +5 more
europepmc   +1 more source

Tumor cell membrane camouflaged liposomal pharmaceuticals for cascade catalysis‐driven redox modulation and synergistic ROS/RNS antitumor therapy

open access: yesVIEW, EarlyView.
A tumor cell membrane camouflaged liposomal nanoplatform (C‐MLip@LA) modulates tumor redox homeostasis to enhance targeted therapy. By encapsulating L‐arginine, anchoring MnO2 nanoparticles, and leveraging homologous membrane‐mediated specificity, C‐MLip@LA efficiently triggers a synergistic ROS/RNS cascade, amplifies immunogenic cell death, and ...
Guangrong Zheng   +7 more
wiley   +1 more source

Torsion of a wandering spleen in a pregnant patient presented with acute abdomen: A case report. [PDF]

open access: yesInt J Surg Case Rep
Chekol AM   +4 more
europepmc   +1 more source

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