Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The environment in which military men, journalists and international and non governmental organizations’ (IO-NGO) personnel develop their work during a war or any armed conflict is already definitely more complicate than in the immediate past.
Pablo Sapag Muñoz de la Peña
doaj
Cross-cultural, transnational or interdisciplinary? Eric Wittkower's psychosomatic medicine and transcultural psychiatry in historical context. [PDF]
Hennig C, Delille E, Müller T.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Beyond compliance: Good citizenship during the COVID-19 pandemic. [PDF]
Clarke N, Barnett C.
europepmc +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Political and Ideological Work in the Southern Battlefield and the Construction of the Vietnamese Revolutionary Image in Foreign Affairs (1954-1975). [PDF]
Phuong NT.
europepmc +1 more source
Control of foot-and-mouth disease in a closed society: A case study of Soviet Estonia. [PDF]
Kass M +4 more
europepmc +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Incidence and risk factors of fracture-related infection after SIGN nailing of open femoral fractures in Ethiopia. [PDF]
Sulala AC +8 more
europepmc +1 more source

