Advanced Science, EarlyView.Lipopolysaccharide (LPS) stimulates the production of succinic acid in lung tissue, which promotes macrophages endocytosis and the formation of multivesicular bodies (MVBs). These MVBs release profibrotic extracellular vesicles (EVs), facilitating the transfer of integrin beta1 (ITGβ1) transfer and subsequently activating fibroblasts, thereby ...
Wenyu Yang +10 more
wiley +1 more source
Advanced Science, EarlyView.Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng +7 more
wiley +1 more source
Cutoff in the Lyman-α forest power spectrum: Warm IGM or warm dark matter?
, 2017 Antonella Garzilli +2 more
openalex +1 more source
Warm dark matter via ultra-violet freeze-in: reheating temperature and non-thermal distribution for fermionic Higgs portal dark matter [PDF]
, 2016 J. McDonald
openalex +1 more source
CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation
Advanced Science, EarlyView.Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao +18 more
wiley +1 more source
Illuminating the darkness: More evidence from faint-star proper-motions for a cool and warm component to the local dark matter in the Galaxy [PDF]
, 2002 R. A. Méndez
openalex +1 more source
Advanced Science, EarlyView.Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan +9 more
wiley +1 more source
Sedimentary Paleoenvironment and Hydrocarbon Generation Potential Evaluation of Middle Jurassic Coal-Measure Source Rocks in the Southern Beishan Area. [PDF]
ACS OmegaWang H +10 more
europepmc +1 more source
Advanced Science, EarlyView.Humanized milk fat globules (MFG) mimic the native composition and structure of human milk, achieved through remodeling of milk fat globule membrane phospholipid composition and reconstruction of the tri‐layer membrane structure. These humanized MFG exhibit improved structural stability and digestibility, and enhance neurodevelopment in formula‐fed rat
Shaolei Wang +8 more
wiley +1 more source
Warming Accelerates Phytoplankton Bloom Dynamics and Differentially Affects the Fluxes of Carbon, Nitrogen, and Oxygen Through a Coastal Microbial Community. [PDF]
Microb EcolLópez-Sandoval DC +3 more
europepmc +1 more source