Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz +9 more
wiley +1 more source
Spacecraft design sensitivity for a disaster warning satellite system [PDF]
A disaster warning satellite (DWS) is described for warning the general public of impending natural catastrophes. The concept is responsive to NOAA requirements and maximizes the use of ATS-6 technology.
Braley, R. C. +4 more
core +1 more source
Preception in the rat: Autonomic response to shock as a function of length of the warning interval. [PDF]
, 1962 The autonomic response (galvanic skin response) to a noxious stimulus (shock) is reduced when the stimulus is preceded by a warning signal. The greatest reduction, 53%, was obtaqined with a warning interval of 1 second.
Lykke, David T.
core
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Teaching or research? What affects the efficiency of universities [PDF]
, 2002 We examine differences in the efficiency of UK universities in providing research and teaching. It appears that (i) universities are more efficient in providing teaching than research, (ii) the variation of efficiency is larger in research than in ...
Lehmann, Erik, Warning, Susanne
core
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants
Annals of Clinical and Translational Neurology, EarlyView.Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold +12 more
wiley +1 more source
Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi +8 more
wiley +1 more source
DESIGN OF A CROSS-BOUNDARY WARNING SYSTEM FOR SOIL PREPARATION BASED ON BDS
, 2019 Guo ChengYang +5 more
openalex +1 more source
Interpretable and Adaptable Early Warning Learning Analytics Model [PDF]
, 2021 Shaleeza Sohail, Atif Alvi, Aasia Khanum
openalex +1 more source
[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich +19 more
wiley +1 more source