Results 51 to 60 of about 51,399 (263)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Climate ServicesThere is an urgent need to implement adaptation measures for weather, climate, and compound extreme events. Here, we present a multi-, inter-, and trans-disciplinary case study on the establishment of a local, operational, integrated, and people-centered
Daniel Ruiz-Carrascal +10 more
doaj +1 more source
Cybergeo, 2017 Information given on flash floods in real time should undoubtedly correspond to the citizens needs as well as to the politics and the safety guidelines.
Johnny Douvinet +4 more
doaj +1 more source
The Safety Monitoring and Warning System for Live Working Based on ToF Technology
Zhongguo dianli, 2020 Aiming at the deficiency of security monitoring and early warning means and methods for live working in China, a ToF (Time of flight)-based real-time safety monitoring and warning system is proposed for live working.
Wen LI +5 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Ts. Dr. Waheb creates Narrowband Internet of Things Enabled Flood Monitoring and Warning System [PDF]
, 2021 A lecturer from the Faculty of Electrical & Electronic Engineering Technology (FTKEE), Universiti Malaysia Pahang (UMP), Ts. Dr. Waheb Abdul Jabbar Shaif Abdullah, 42, created a system called Narrowband Internet of Things Enabled Flood Monitoring and ...
Nur Hartini, Mohd Hatta +1 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2016 This paper proposes the drive training assistant system for ambulance drivers to avoid the excessive blood pressure variation of patients caused by brake operation. The system has two functions.
Takahiko ONO, Yukio MAKINO
doaj +1 more source
Simulation of an Early Warning Fire System
, 2019 In this paper, we will be using separate software tools (wireless network and Finite Differences Time Domain based simulators) to simulate the implementation of a wireless sensor network model based on low-rate/power transmission technology. The system operates in an unlicensed frequency range and the sensing nodes rely on surface plasmon resonance ...
Lourenço, Paulo +2 more
openaire +3 more sources
A new approach to designing lateral collision warning systems
, 2007 According to the National Highway Traffic Safety Administration (NHTSA), more than 43% of all fatal accidents reported in 2001 involved a lane or road departure.
Stanton, Neville A +11 more
core +1 more source