Results 251 to 260 of about 4,345 (311)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown   +2 more
wiley   +1 more source

FastSurfer parcellation accuracy after lesion filling in moderate-to-severe traumatic brain injury. [PDF]

open access: yesFront Neurol
Deutscher E   +13 more
europepmc   +1 more source

Geometric topology of CR-warped products in six-dimensional sphere

open access: gold
Noura Alhouiti   +4 more
openalex   +1 more source

Femtosecond Laser Created Corneal Allogenic Intrastromal Ring Segments for Keratoconus

open access: yesClinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To evaluate the clinical outcomes of femtosecond laser‐created corneal allogenic intrastromal ring segments (femto‐CAIRS) in keratoconic eyes using a newly described nomogram. Methods This retrospective case series recruited 85 eyes from 75 patients.
David J. Gunn   +2 more
wiley   +1 more source

Robust automated preclinical fMRI preprocessing via a multi-stage dilated convolutional Swin Transformer affine registration. [PDF]

open access: yesFront Neurosci
Soltanpour S   +7 more
europepmc   +1 more source

Fused Collapsing for Wide BVH Construction

open access: yesComputer Graphics Forum, EarlyView.
Abstract We propose a novel approach for constructing wide bounding volume hierarchies on the GPU by integrating a simple bottom‐up collapsing procedure within an existing binary bottom‐up BVH builder. Our approach directly constructs a wide BVH without traversing a temporary binary BVH as done by previous approaches and achieves 1.4 – 1.6 × lower ...
Wilhem Barbier, Mathias Paulin
wiley   +1 more source

Neurocognition, cerebellar functions and psychiatric features in spinocerebellar ataxia type 34: a case series. [PDF]

open access: yesFront Comput Neurosci
Cundari M   +11 more
europepmc   +1 more source

Image‐Based Spatio‐Temporal Interpolation for Split Rendering

open access: yesComputer Graphics Forum, EarlyView.
Abstract Low‐powered devices – such as small form factor head‐mounted displays (HMDs) – struggle to deliver a smooth and high‐quality viewing experience, due to their limited power and rendering capabilities. Cloud rendering attempts to solve the quality issue, but leads to prohibitive latency and bandwidth requirements, hindering use with HMDs over ...
M. Steiner   +4 more
wiley   +1 more source

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