Results 91 to 100 of about 969,539 (294)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

In situ Soil Washing on Metal-Contaminated Sandy Soil by Sedimentation Method: A New Approach on Soil Remediation [PDF]

, 2010
We propose a new approach of in situ soil remediation called in situ soil washing by sedimentation method, by injecting high air pressure into mixing water-sandy soil ground and hydraulically separate soil particles based on their particle size
Ohta, Hideki, Hinode, Hirofumi, Budianta, Wawan, Salim, Chris   +3 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Green Washing Won't Wash

Shanlax International Journal of Arts, Science and Humanities
This research paper explores greenwashing, a deceptive marketing practice employed by corporations to create a misleading perception of their environmental responsibility. Through a comprehensive analysis of academic literature, case studies, and industry reports, this paper highlights the various tactics companies use to greenwash their products and ...
Thirupathi Manickam, D P Samriddha
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Digitally printed cotton fabric – the influence of washing conditions

Koža i Obuća
The aim of this study was to investigate the effects of washing on cotton fabric digitally printed in blue colour. The study included several important steps: the selection of the most suitable detergent and washing temperature, the analysis of the ...
Tihana Dekanić, Martina Glogar, Tena Margan, Tanja Pušić, Suzana Đorđević   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Recycling of solvent used in a solvent extraction of petroleum hydrocarbons contaminated soil. [PDF]

, 2011
The application of water washing technology for recycling an organic composite solvent consisting of hexane and pentane (4:1; TU-A solvent) was investigated for extracting total petroleum hydrocarbons (TPH) from contaminated soil. The effects of water
Frédéric Coulon, Li, Xingang, Li, Hong, Hong Li, Coulon, Frederic, Sui, Hong, Jingyan Lian, Lian, Jingyan, Xingang Li, Wu, Guozhong, Guozhong Wu, Hong Sui   +11 more
core   +1 more source

Lipase-Assisted Removal of Spin Finishes from Synthetic Fibre Textiles

Textiles
Lubricants based on fatty acid ester (FAE) mixtures are widely used in the textile industry, e.g., in spin finishes applied during the production of synthetic fibres, or in sizes added to fibres before weaving. FAE lubricants can significantly impact the
Luís C. de Sousa, Paula Vidal, Rebecka Molitor, Stephan Thies, Jan Modregger, Simona Capone, Karl-Erich Jaeger, Nazanin Ansari, Roland Lottenbach, Rainer Rösch, Manuel Ferrer, Carla C. C. R. de Carvalho   +11 more
doaj   +1 more source