Results 111 to 120 of about 209,692 (271)

Prevalence and impact of prescribing cascades in community‐dwelling adults: Longitudinal analysis of the Irish longitudinal study on ageing (TILDA)

British Journal of Clinical Pharmacology, EarlyView.
Prescribing cascades occur when medication is prescribed to prevent/treat the adverse effects of another medication and may be intentional/unintentional. This study examines the prevalence of nine prescribing cascades (ThinkCascades) in The Irish Longitudinal StuDy on Ageing (TILDA).
Ann Sinéad Doherty, Rose Anne Kenny, Frank Moriarty, Fiona Boland, Barbara Clyne, Tom Fahey, Denis O' Mahony, Emma Wallace   +7 more
wiley   +1 more source

Diagnostic utilities of washout CYFRA 21-1 combined with washout thyroglobulin for metastatic lymph nodes in thyroid cancer: a prospective study

Scientific Reports
Cervical lymph node (LN) metastasis is common in differentiated thyroid cancer (DTC). This study evaluated the utility of the washout CYFRA 21-1 level, combined with the thyroglobulin (Tg) concentration, in terms of diagnosis of LN metastasis.
Joonseon Park, Solji An, Kwangsoon Kim, Jeong Soo Kim, Chan Kwon Jung, Ja Seong Bae   +5 more
doaj   +1 more source

Effects of flow regime on the young stages of salmonid fishes. Summary and conclusions based on results for 1981-1985 [PDF]

, 1985
The main British salmonid species spawn in clean gravel in streams and rivers, many of them in the upland areas of Britain. The earliest stages of the life cycle (eggs and alevins) spend some months within the gravel of the river bed.
Crisp, D.T.
core  

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Radiological and histopathological analyses of two bile duct adenoma cases focused on washout in the portal phase of contrast-enhanced ultrasound

, 2021
Soo Ki Kim, T. Fujii, Soo Ryang Kim, Hisato Kobayashi, Toyokazu Okuda, Takanobu Hayakumo, Yumi Fujii, Atsushi Nakai, Aya Ohtani, Ke-Ih Kim, Osamu Nakashima, Tsutomu Kumabe, Motoko Sasaki, Yu‐ichiro Koma, Soichi Kubo, Hiroshi Yasui, Takakazu Matsushita, Hironori Tanaka, Akira Yamada   +18 more
openalex   +2 more sources

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Patient and healthcare professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: qualitative study of the CATHETER II trial

BMJ Open
Objectives To explore trial participants’ experience of long-term catheters (LTC), the acceptability of washout policies, their experience of the CATHETER II trial (a randomised controlled trial comparing the clinical effectiveness of various washout ...
John Norrie, Graeme Maclennan, David Cooper, Paul Little, Peter Murchie, Phyo Kyaw Myint, Mohamed Abdel-fattah, Mary Kilonzo, Muhammad Imran Omar, Diana Johnson, Sara J Maclennan, James Ndow, Graham Scotland, Amanda Young, Seonaidh Cotton, Nikesh Thiruchelvam, Catherine Paterson, Lynda Constable, Hashim Hashim, Sheela Tripathee, Konstantinos Dimitropoulos, Suzanne Evans, Karen Powell, James Hugh Larcombe   +23 more
doaj   +1 more source

Estimation of the in situ degradation of the washout fraction of starch by using a modified in situ protocol and in vitro measurements

Animal, 2015
The in situ degradation of the washout fraction of starch in six feed ingredients (i.e. barley, faba beans, maize, oats, peas and wheat) was studied by using a modified in situ protocol and in vitro measurements.
L.H. de Jonge, H. van Laar, J. Dijkstra
doaj   +1 more source

Aspects of thermal leptogenesis in braneworld cosmology

, 2005
The mechanism of thermal leptogenesis is investigated in the high-energy regime of braneworld cosmology. Within the simplest seesaw framework with hierarchical heavy Majorana neutrinos, we study the implications of the modified Friedmann equation on the ...
J. E. Lidsey, M. C. Bento, M. Gell-Mann, N. M. C. Santos, R. González Felipe, R. Maartens, S. L. Glashow, T. Yanagida   +7 more
core   +1 more source

Pharmacokinetics and pharmacodynamics of intravenous and oral (S)‐ketamine: Investigating metabolite contribution to subjective effects

British Journal of Clinical Pharmacology, EarlyView.
Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto, Gabriël E. Jacobs, Joost C. van Mechelen, Laura G. J. M. Borghans, Johan G. C. van Hasselt, Linda B. S. Aulin   +5 more
wiley   +1 more source