Results 41 to 50 of about 209,692 (271)

Association between irrigation fluids, washout volumes and risk of local recurrence of anterior resection for rectal cancer: a meta-analysis of 427 cases and 492 controls. [PDF]

PLoS ONE, 2014
BACKGROUND: Rectal washout can prevent local recurrence after anterior resection of rectal cancer. Few studies have focused particularly on the association between irrigation fluids volume or agents and the risk of local recurrence after anterior ...
Can Zhou, Yu Ren, Juan Li, Ke Wang, Jianjun He, Wuke Chen, Peijun Liu   +6 more
doaj   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming. [PDF]

, 2016
The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor ...
Bagai, Rakesh, Bivona, Trever G, Danielpour, David, Feng, Yan, Leahy, Patrick, Lindner, Daniel, Ma, Patrick C, Rosell, Rafael, Shi, Ivy, Thiagarajan, Praveena S, Veigl, Martina, Wu, Xiaoliang, Yin, Lihong, Zhang, Wei, Zhang, Zhenfeng   +14 more
core   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Fine-needle Aspiration Washout Precipitation Specimens: An Acceptable Supplement to Genetic Mutation Detection of Thyroid Nodules

Technology in Cancer Research & Treatment, 2021
Objectives: Thyroid nodules are common in adults, but only some of them are malignant. Ultrasound-guided fine-needle aspiration (FNA) is widely applied as a reliable and minimally invasive technique for evaluating thyroid nodules.
Yongmei Cui MD, Xiangqi Huang MD, Jinrui Guo MS, Nana Zhang MD, Jing Liang MD, Yiwang Zhang MD, Yueting Liao MD, Dan He MD   +7 more
doaj   +1 more source

Baryon asymmetry from leptogenesis with four zero neutrino Yukawa textures [PDF]

, 2011
The generation of the right amount of baryon asymmetry $\eta$ of the Universe from supersymmetric leptogenesis is studied within the type-I seesaw framework with three heavy singlet Majorana neutrinos $N_i\,\,(i = 1,2,3)$ and their superpartners.
A. Abada, A. Abada ., Ambar Ghosal, B. Adhikary, Biswajit Adhikary, C.S. Fong, E. Nardi, E.W. Kolb, G.L. Fogli, H. Minakata, I. Aizawa, J.C.B. Sanchez, L. Canetti, L. Covi, M. Drees, M. Gell-Mann, M. Trodden, M.Y. Khlopov, N. Nimai Singh, Probir Roy, R.N. Mohapatra, S. Antusch, S.-F. Ge, T. Fukuyama, T. Yanagida, W. Grimus, W. Rodejohann, WMAP collaboration, WMAP collaboration   +28 more
core   +2 more sources

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Arthroscopic washout of the knee: a procedure in decline. [PDF]

, 2014
BACKGROUND: Osteoarthritis (OA) of the knee is a chronic, progressive condition which often requires surgical intervention. The evidence for the benefits of arthroscopic debridement or washout for knee OA is weak and arthroscopy is currently only ...
American Academy of Orthopaedic Surgeons, Andersson-Molina, Arthritis Care, Bernard, Burr, Cameron-Donaldson, Caroline Hing, Cicuttini, Clements, Cooper, Dhawan, Felson, Grenier, Hospital Episode Statistics: Health and Social Care Information Centre, Jason Bernard, Lane, Laupattarakasem, Loeser, Losina, National Institute for Health and Care Excellence, National Institute for Health and Clinical Excellence, Oliver Boughton, Rosenthal, Sihvonen, Sowers, Spector, Srikanth, Stefan Lazic, Zhang   +28 more
core   +1 more source

“Normative data for multiple breath washout outcomes in school-aged Caucasian children.” Pinelopi Anagnostopoulou, Philipp Latzin, Renee Jensen,et al. Eur Respir J2020; 55: 1901302. [PDF]

, 2022
F Wyler, M Oestreich, B Frauchiger, A-C Kentgens, P Latzin, P Anagnostopoulou   +5 more
openalex   +1 more source

Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy

Advanced Science, EarlyView.
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge, Chengsheng Ding, Xiao Yang, Si Gao, Changjie Yang, Yuchen Hou, Hongye Wang, Linke Bian, Hao Zhong, Yifan Qu, Luyang Zhang, Junjun Ma, Zhengwei Cai, Wenguo Cui, Minhua Zheng   +14 more
wiley   +1 more source