Results 61 to 70 of about 209,692 (271)

Multimodal Imaging of Ductal Carcinoma In Situ: A Single-Center Study of 75 Cases

Medical Sciences
Introduction: Ductal carcinoma in situ (DCIS) is a non-invasive precursor of breast cancer, usually detected on mammography as clustered microcalcifications. Many cases, however, lack calcifications and require complementary imaging.
Fabrizio Urraro, Nicoletta Giordano, Vittorio Patanè, Maria Chiara Brunese, Carlo Varelli, Carolina Russo, Luca Brunese, Salvatore Cappabianca   +7 more
doaj   +1 more source

Qualitative and Quantitative Assessment of Enhancement and Washout Characteristics of HCC and non HCC Hypervascular Liver Tumours [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: The image based diagnosis of Hepatocellular Carcinoma (HCC) relies on assessment of arterial enhancement and venous or delayed phase washout.
Prerna Garg, Salil Pandey, Muthusubramanian, Cindrel, B Devanand, V Maheshwaran, R Rajakumar   +6 more
doaj   +1 more source

Low-scale leptogenesis with three heavy neutrinos

, 2018
Leptogenesis induced by the oscillations of GeV-scale neutrinos provides a minimal and testable explanation of the baryon asymmetry of the Universe. In this work we extend previous studies invoking only two heavy neutrinos to the case of three heavy ...
Abada, Asmaa, Arcadi, Giorgio, Domcke, Valerie, Drewes, Marco, Klaric, Juraj, Lucente, Michele   +5 more
core   +4 more sources

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Washout on Contrast-Enhanced Ultrasound of Benign Focal Liver Lesions—A Review on Its Frequency and Possible Causes

Diagnostics
In all imaging methods, including contrast-enhanced ultrasound (CEUS), enhancement in the late phase (LP) is an important criterion for differentiating between benign and malignant focal liver lesions (FLLs).
Kathleen Möller, Christian Görg, Martin Krix, Christian Jenssen, Yi Dong, Xin-Wu Cui, Christoph F. Dietrich   +6 more
doaj   +1 more source

Exotic fermion multiplets as a solution to baryon asymmetry, dark matter and neutrino masses

, 2012
We propose an extension to the standard model where three exotic fermion 5-plets and one scalar 6-plet are added to the particle content. By demanding that all interactions are renormalizable and standard model gauge invariant, we show that the lightest ...
Chuan-Hung Chen, E. Aprile, M. Gell-Mann, P. L. Brink, S. L. Glashow, Sandy S. C. Law   +5 more
core   +1 more source

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation [PDF]

, 2014
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures
Amin R, Andrea Venerando, Angela Sepe, Anil Mehta, Anna Bossi, Anna Zolin, Antonella Tosco, Boyle MP BS, Carlo A Leone, Daniela De Stefano, Donaldson S., Fabiola De Gregorio, Fischer H, Gianni Bona, Gibson LE, Giuseppe De Rosa, Guido Kroemer, Illek B, Jayaraman S, Kerem B, Kerem Eithan HMO, Laura Salvadori, Legssyer R, Lorenzo A Pinna, Luigi Maiuri, Lukacs G, Maria C Maiuri, Massimo Pettoello-Mantovani, Masvidal L, Pharmaceuticals Cylene, Pharmaceuticals Cylene, Rosa Grassia, Speranza Esposito, Standardization of Spirometry, Stefano Guido, Stern M, Valeria R Villella, Valeria Raia, van Doorninck JH, Villella VR   +39 more
core   +4 more sources

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Leptogenesis with Dirac Neutrinos [PDF]

, 2000
We describe a "neutrinogenesis" mechanism whereby, in the presence of right-handed neutrinos with sufficiently small pure Dirac masses, (B+L)-violating sphaleron processes create the baryon asymmetry of the Universe, even when B=L=0 initially.
A. D. Sakharov, A. D. Sakharov, D. V. Nanopoulos, D. Wright, E. W. Kolb, E. W. Kolb, J. A. Harvey, J. Liu, J. N. Fry, K. Dick, K. Zuber, M. A. Luty, M. Fukugita, M. Lindner, M. Ratz, S. Burles, V. A. Kuzmin   +16 more
core   +2 more sources

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Advanced Science, EarlyView.
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach   +8 more
wiley   +1 more source