Results 261 to 270 of about 96,401 (352)

Equine botulism

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik   +2 more
wiley   +1 more source

Tks5 interactome reveals endoplasmic‐reticulum‐associated translation machinery in invadosomes

open access: yesThe FEBS Journal, EarlyView.
Invadosomes—dynamic structures enabling matrix invasion—include rosettes, dots, and linear forms, depending on cell type and context. Using the invadosome marker Tks5 (SH3PXD2A), we identified shared molecular features across cell types. Mass spectrometry revealed components of the translation machinery, notably EIF4B, and ER‐associated proteins within
Léa Normand   +11 more
wiley   +1 more source

Highly divergent apicomplexan cytoskeletons provide additional models for actin biology

open access: yesThe FEBS Journal, EarlyView.
Actin is a highly conserved, abundant and central molecule in eukaryotes. Apicomplexans contain some of the most sequence‐divergent actin cytoskeletons known. This divergence results in overlapping yet different biochemical properties. Here, we highlight the remarkable divergence of the actin cytoskeleton by comparing apicomplexan to classical systems,
Yukino Kobayashi, Ross G. Douglas
wiley   +1 more source

Structural and functional dissection of the WH2/DAD motif of INF2, a formin linked to human inherited degenerative disorders

open access: yesThe FEBS Journal, EarlyView.
The INF2 WH2/DAD domain, composed of hydrophobic and basic regions, forms a single α‐helix in solution. The hydrophobic segment is essential for INF2 function, as its deletion disrupts actin dynamics and causes nuclear abnormalities, like those seen in pathogenic INF2 DID variants. In contrast, natural INF2 WH2/DAD variants found in patients with renal
Leticia Labat‐de‐Hoz   +5 more
wiley   +1 more source

TOWARD A CONJECTURAL HISTORY OF CONJECTURAL HISTORIES

open access: yesHistory and Theory, EarlyView.
ABSTRACT Most intellectual historians use the term “conjectural history” to designate a new form of speculative history created in eighteenth‐century Scotland by Adam Smith and a few others. These writers traced the development of human society and culture through conjectural reasoning based on philosophers’ views about human nature and travelers ...
ANTHONY GRAFTON
wiley   +1 more source

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