Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo +11 more
wiley +1 more source
The role of the 5f valence orbitals of early actinides in chemical bonding
Understanding the chemistry of heavy radioactive elements is crucial to harnessing them for fuel and medicine. Here, the authors combine advanced X-ray spectroscopy and modelling to the study the chemical bonding of the 5fvalence orbitals of uranium ...
T. Vitova +11 more
doaj +1 more source
Observer‐Based Adaptive Event‐Triggered Tracking Control for Fuzzy TS Systems With Premise Mismatch
This paper presents an adaptive logistic event‐triggered observer‐based tracking controller for Takagi‐Sugeno fuzzy systems under constrained inputs and network delays. Leveraging a hybrid LMI and Secretary Bird Optimization approach, this strategy significantly minimizes communication overhead and computational burden while ensuring optimal reference ...
Oussama Djadane +3 more
wiley +1 more source
The European Union aims to recycle 60% of its total waste by 2030, for which waste collection infrastructure and the source-separation behaviour of waste producers are among the crucial prerequisites.
Namrata Mhaddolkar +2 more
doaj +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Discard studies have demonstrated that waste is more than just a symptom of an all-too-human demand for meaning or a merely technical problem for sanitary engineers and public health officials. The afterlife of waste materials and processes of waste management reveal the centrality of transient and discarded things for questions of materiality and ...
openaire +3 more sources
Cellulase extraction from Pseudomonas fluorescens for efficient enzymatic hydrolysis and fermentation with Pichia fermentans and Saccharomyces cerevisiae for cellulosic bioethanol production [PDF]
Cellulase enzymes of Pseudomonas fluorescens were extracted for the efficient Enzymatic hydrolysis of horticultural plant wastes. Horticultural plant rejects (shoots and leaves) of Tuber plants like Taro, giant Taro, Elephant yam and Potato were used as ...
N Hemasree, S S Dawn
doaj +1 more source
Entropy‐Driven Design of Low‐Melting‐Point Alloys via Compositionally Complex Strategy
Conventional low‐melting‐point alloys (LMPAs) are limited by a narrow compositional space and inherent property trade‐offs. This review presents an entropy‐driven design strategy that overcomes these limitations, ushering in a new class of low‐melting‐point compositionally complex alloys (LMCCAs).
Yinghui Shang +6 more
wiley +1 more source
Final report : baseline survey for waste-to-energy pilot in Malang Regency
ESCAP and its partners undertake solid waste management assessments (baseline surveys) in all cities prior to establishing waste-to-resource initiatives.
UN.ESCAP +3 more
core +1 more source
To waste or not to waste – food? [PDF]
Emmanuel C, Gentil, Tjalfe G, Poulsen
openaire +2 more sources

