Results 51 to 60 of about 167,369 (311)

Sustainability: Don't waste seafood waste [PDF]

Nature, 2015
Turning cast-off shells into nitrogen-rich chemicals would benefit economies and the environment, say Ning Yan and Xi Chen.
Ning, Yan, Xi, Chen
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Selective activation of the unfolded protein response and proteolytic pathways in sarcopenic limb muscles of bronchiectasis patients

ERJ Open Research
Introduction Sarcopenia contributes significantly to decreased exercise tolerance, reduced quality of life and worse overall prognosis, independent of lung function severity in chronic respiratory disease including bronchiectasis.
Adriana Núñez-Robainas, Alberto Solano, Salvatore Marsico, Mariela Alvarado-Miranda, Maria Cinta Cumpli-Gargallo, Marina Sáinz-Hernández, José María Maiques, Esther Barreiro   +7 more
doaj   +1 more source

How does baseline anthropometry affect anthropometric outcomes in children receiving treatment for severe acute malnutrition? A secondary analysis of a randomized controlled trial

Maternal and Child Nutrition, 2022
Mid‐upper arm circumference (MUAC) 
Clarisse Dah, Millogo Ourohire, Ali Sié, Moussa Ouédraogo, Mamadou Bountogo, Valentin Boudo, Elodie Lebas, Fanice Nyatigo, Benjamin F. Arnold, Kieran S. O'Brien, Catherine E. Oldenburg   +10 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Child stunting starts in utero: Growth trajectories and determinants in Ugandan infants

Maternal and Child Nutrition, 2022
Childhood stunting remains a public health burden worldwide. Although many studies have examined early life and in‐utero risk factors; most have been observational and have used analytic techniques that make inferences limited to population means ...
Grace Namirembe, Shibani Ghosh, Lynne M. Ausman, Robin Shrestha, Sonia Zaharia, Bernard Bashaasha, Nassul Kabunga, Edgar Agaba, Julieta Mezzano, Patrick Webb   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dystrophin glycoprotein complex dysfunction:a regulatory link between muscular dystrophy and cancer cachexia [PDF]

, 2005
Cachexia contributes to nearly a third of all cancer deaths, yet the mechanisms underlying skeletal muscle wasting in this syndrome remain poorly defined.
Butchbach, Matthew E R, Burghes, Arthur H M, Guttridge, Denis C, Sahenk, Zarife, Saji, Motoyasu, Acharyya, Swarnali, Ringel, Matthew D, Skipworth, Richard J E, Rafael-Fortney, Jill A, Wang, Huating, Ringel, Matthew D., Hollingsworth, Michael A, Carathers, Micheal, Fearon, Kenneth C H, Butchbach, Matthew E.R., Hollingsworth, Michael A., Muscarella, Peter, Guttridge, Denis C., Rafael-Fortney, Jill A., Skipworth, Richard J.E., Burghes, Arthur H.M., Fearon, Kenneth C.H.   +21 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Water Matters More: Unequal Effects of Water and Sanitation on Child Growth in Mozambique

Children
Background: Child stunting and wasting persist at alarmingly high rates in Mozambique, yet little is known about whether the improved sources of water and sanitation affect these outcomes differently.
Jailene P. Castillo, Christina A. Molinaro, William E. Pater, Santosh K. Gautam   +3 more
doaj   +1 more source