Results 61 to 70 of about 103,186 (245)
Exercise intolerance and fatigue in chronic heart failure: is there a role for group III/IV afferent feedback? [PDF]
, 2020 Exercise intolerance and early fatiguability are hallmark symptoms of chronic heart failure. While the malfunction of the heart is certainly the leading cause of chronic heart failure, the patho-physiological mechanisms of exercise intolerance in these ...
Angius, Luca, Crisafulli, Antonio
core +2 more sources
Frailty Exacerbates Disability in Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks +10 more
wiley +1 more source
, 2006 JC is a 13 year old boy who presented with a 3 week history of anterior right knee pain. Pain is activity related and brought on whenever JC plays football or basketball. He never needed to stop from any particular activity because of the pain.
Formosa, Aaron
core +1 more source
Kidney International Reports, 2017 It is unknown whether the criteria used to define protein−energy wasting (PEW) syndrome in dialysis patients reflect protein or energy wasting in the general and moderate CKD populations.
Srinivasan Beddhu +8 more
doaj +1 more source
Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness [PDF]
, 2014 Muscle wasting and cachexia are important systemic manifestations of highly prevalent conditions including cancer. Inflammation, oxidative stress, autophagy, ubiquitin-proteasome system, nuclear factor (NF)-kB, and mitogen activated protein kinases (MAPK)
Bal, Elisa Dora +7 more
core +1 more source
Cardiac cachexia in sub-Saharan Africa
Indian Heart Journal, 2017 Cachexia is a public health challenge around the Globe but data on prevalence rates in developing countries are very scarce. In sub-Saharan Africa wasting syndrome is mainly related to malaria, HIV infections, tuberculosis and end-stage heart disease and
Antonio Grimaldi +3 more
doaj +1 more source
Advanced cancer is also a heart failure syndrome: a hypothesis
Journal of Cachexia, Sarcopenia and Muscle, 2021 We present the hypothesis that advanced stage cancer is also a heart failure syndrome. It can develop independently of or in addition to cardiotoxic effects of anti‐cancer therapies. This includes an increased risk of ventricular arrhythmias.
Markus S. Anker +7 more
doaj +1 more source
Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death [PDF]
, 2018 The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches.
Cordero, Julia B. +2 more
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Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice
Reproductive Biology and Endocrinology, 2010 Background Inhibin is a tumor-suppressor and activin antagonist. Inhibin-deficient mice develop gonadal tumors and a cachexia wasting syndrome due to enhanced activin signaling.
Weinstein Michael B +6 more
doaj +1 more source
Six-Month Mortality among HIV-Infected Adults Presenting for Antiretroviral Therapy with Unexplained Weight Loss, Chronic Fever or Chronic Diarrhea in Malawi. [PDF]
, 2012 In sub-Saharan Africa, early mortality is high following initiation of antiretroviral therapy (ART). We investigated 6-month outcomes and factors associated with mortality in HIV-infected adults being assessed for ART initiation and presenting with ...
AD Kerkhoff +50 more
core +3 more sources