Results 231 to 240 of about 12,766,596 (284)

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Water-Energy-Food Nexus KAN

TRENDS IN THE SCIENCES, 2018
openaire   +1 more source

Food-energy-water nexus: A life cycle analysis on virtual water and embodied energy in food consumption in the Tamar catchment, UK [PDF]

Resources, Conservation and Recycling, 2018
Evaluations of food, energy and water (FEW) linkages are rapidly emerging in contemporary nexus studies. This paper demonstrates, from a food consumption perspective, the potential of life cycle thinking in understanding the complex and often "hidden ...
Gloria Salmoral, Xiaoyu Yan
exaly   +7 more sources

The water–energy–food nexus

, 2022
As the consequences of climate change continue to unfold globally, effective adaptation strategies are critical. There are many uncertainties inherent in climate change adaptation.
Sally Williams, Annette Huber-Lee, Laura Forni, Youssef Almulla, Camilo Ramirez Gomez, Brian Joyce, Francesco Fuso-Nerini   +6 more
core   +3 more sources

Water-energy-food nexus: Concepts, questions and methodologies [PDF]

Journal of Cleaner Production, 2018
The water-energy-food nexus has gained increasing attention in the research communities as the security of water, energy and food becomes a very high concern due to future uncertainties.
Yu Li, Guangtao Fu
exaly   +7 more sources

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The water-energy-food nexus

2019
Energy interacts with other resources and factors, often with negative consequences in the form of either resource waste or environmental damage. In other words, clean energy is not just about energy itself but also about the interactions of the energy supply chain with other resources.
Nikolai Mouraviev, Anastasia Koulouri
openaire   +2 more sources

Water Energy Food Nexus

2020
The correlation and integration between water, energy and food (WEF) comes true and becomes so close. We will never use the terms again, such as “the future of food production”, or the “future of energy security”, or the future of water demands.
openaire   +1 more source

Handbook on the Water-Energy-Food Nexus

2022
This Handbook provides a comprehensive overview of how water, energy and food are interconnected, comprising a coherent system: the nexus. It considers the interlinkages between natural resources, governance processes seeking coherence among water, energy and food policies, and the adoption of transdisciplinary approaches in the field.
openaire   +2 more sources