Results 41 to 50 of about 12,493,917 (291)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Water-Energy-Food Nexus Index: A Tool to Support Integrated Resource Planning, Management and Security

Frontiers in Water, 2022
The call for measuring synergies and trade-offs between water, energy, and food is increasing worldwide. This article presents the development and application of a country-level index that has been calculated for 181 nations using open databases ...
Gareth B. Simpson, Gareth B. Simpson, Graham P. W. Jewitt, Graham P. W. Jewitt, William Becker, Jessica Badenhorst, Sara Masia, Sara Masia, Ana R. Neves, Pere Rovira, Victor Pascual   +10 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Indicator-Based Evaluation of Türkiye’s Water–Energy–Food Nexus Profile for Sustainable Development

Journal of Agricultural Sciences
The Water–Energy–Food (WEF) Nexus rests on the reality that interlinkages among resources are mutually interdependent; changes in one sector can have significant repercussions in the others.
Mehmet Ali Dayıoğlu, Maksut Barış Eminoğlu   +1 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Water-energy-food nexus in China: An interregional comparison

Agricultural Water Management
The geographical mismatch between water availability and demand further exacerbates the challenge of the water-energy-food nexus in China. This study characterizes competing water uses for crops and energy to reveal their resulting impacts on regional ...
Yuqin Li, Lixiao Zhang, Pengpeng Zhang, Xinqing Li, Yan Hao   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Quantifying the coordination of the water-energy-food nexus and its drivers in Africa

Energy Nexus
The water-energy-food (WEF) nexus in Africa faces mounting pressures from climate change, population expansion, environmental degradation, intense resource competition, and fragmented sectoral planning.
Romaine Ingabire, Xiaolu Chen, Hubert Hirwa, Yan-Jun Shen   +3 more
doaj   +1 more source