Results 131 to 140 of about 18,116,413 (332)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
IWMI Research Update: news of the progress and impact of IWMI's research [PDF]
Drought, Groundwater, Erosion, Wetlands, Irrigation management, Rainfed farming, Turkey, South East Asia, Sri Lanka ...
International Water Management Institute (IWMI).
core
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Water Figures Asia: news of IWMI’s work in Asia [PDF]
Watersheds, Erosion, Land use, Groundwater, Governance, Training, Asia ...
International Water Management Institute (IWMI).
core +3 more sources
Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media [PDF]
Alexandra Teleki +2 more
openalex +1 more source
Standard Methods for the examination of water and wastewater
Awwa, Wef
semanticscholar +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source

