Results 171 to 180 of about 8,486,155 (235)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Enhancing the Phenolic Value of Polyphenol-Rich Extra Virgin Olive Oils Through Optimized Water Extraction, Macroporous Resin Recovery and Spray Drying. [PDF]

Molecules
Gerasopoulos A, Kachrimanis K, Lazari D.
europepmc   +1 more source

Statistical damage model of rock considering pore water pressure and multifractal characteristics. [PDF]

PLoS One
Zhang Y, Li F.
europepmc   +1 more source

Water quality as an economic barrier to photocatalytic green hydrogen production. [PDF]

RSC Adv
Khan A, Tuna Genc M, Patir IH, Ersoz M.
europepmc   +1 more source

Distilled Water Dilution Increases Measured Fecal pH in Fresh Canine Feces. [PDF]

Animals (Basel)
Marchi PH, Micheletti CD, de Souza JM, Finardi GLF, Fernandes EL, Santiago NS, Dos Santos LD, Dos Santos MH, Balieiro JCC, Vendramini THA.   +9 more
europepmc   +1 more source

First-Principles Insights into Coverage-Dependent Water Adsorption Mechanisms on Representative Lunar Regolith Mineral Surfaces. [PDF]

Materials (Basel)
Deng X, Hong Y, Wang X, Ye X, Xue H, He C, Wang J, Tang F.   +7 more
europepmc   +1 more source

Morphological and Ecological Traits Explain Variation in Desiccation Tolerance Among Bees. [PDF]

Ecol Evol
Gonzalez VH, Dreusicke A, Johnson MG, Tscheulin T, Petanidou T, Hranitz JM, Barthell JF.   +6 more
europepmc   +1 more source