Results 151 to 160 of about 60,917 (260)

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Identification and Spatial Differentiation of High-Risk Areas for Brown Bear Incidents in Yushu Prefecture, China, Using Machine Learning and Remote Sensing. [PDF]

Animals (Basel)
Guo X, Zhao J, Sun Y, Zhai B, Ai X.
europepmc   +1 more source

Highly Entangled Bottlebrush Polymer Networks

Advanced Materials, EarlyView.
Bottlebrush polymers are difficult to entangle, enabling ultrasoft yet brittle networks. We report highly entangled bottlebrush elastomers that remain ultrasoft (∼1 kPa) yet stretch to ∼1800% and exhibit exceptional fatigue resistance. Their intrinsic fatigue strength—fatigue threshold normalized by modulus—surpasses that of highly entangled linear ...
Myoeum Kim, Baiqiang Huang, Shiwang Cheng, Li‐Heng Cai   +3 more
wiley   +1 more source

Rivers constrain female but not male dispersal and genetic structure in brown bears. [PDF]

Sci Rep
Spitzer R, Norman AJ, Schneider M, Sahlén E, Spong G.   +4 more
europepmc   +1 more source

Mechanically Robust and Depolymerizable Polyesters With Near‐Complete Monomer Recovery for Circular Additive Manufacturing

Advanced Materials, EarlyView.
A sustainable δ‐lactone‐based polymer platform enables multimodal additive manufacturing through DLP, DIW, and FFF, combining tunable crystallinity, photocurable networks, mechanical robustness, and functional response. The printed materials can be mechanically reprocessed and chemically depolymerized into recoverable monomers, demonstrating a closed ...
Farzad Gholami, Rampi Ramprasad, H. Jerry Qi   +2 more
wiley   +1 more source

Environmental Parameters as Indicators of Bear Welfare. [PDF]

Zoo Biol
Fourage A, Shepherd CR, Nekaris KAI, Nijman V.   +3 more
europepmc   +1 more source

Meniscus‐Guided Interfacial Ring‐by‐Ring Assembly for In Situ Fabrication of Tubular Hydrogels

Advanced Materials, EarlyView.
A tubular hydrogel fabrication method leveraging the meniscus effect at the oil‐water interface is presented. UV irradiation across the concave surface of the photocurable hydrogel precursor induces the formation of ring‐like hydrogel structures. Sequential ring‐by‐ring assembly within microchannels enables the construction of arteriole‐scale hydrogel ...
Yuki Kamiya, Yingzhe Wang, Keisuke Morishima   +2 more
wiley   +1 more source

Antennal sensilla and brain morphology during development in caddisflies. [PDF]

Cell Tissue Res
Piersanti S, Rebora M, Salerno G, Anton S.   +3 more
europepmc   +1 more source

Can Elastomers Combine Stiffness, Toughness and Fatigue Resistance?

Advanced Materials, EarlyView.
This review studies how the molecular and macroscopic architecture of elastomers influence their mechanical properties including: stiffness, stretchability, toughness, fatigue resistance, and damping behavior. By linking the structure to performance, it proposes design principles for advanced elastomeric systems that combine mechanical properties ...
Eva Baur, Esther Amstad
wiley   +1 more source

Spatial overlap of sea ice-associated predators and prey in western Hudson Bay. [PDF]

PLoS One
Warret Rodrigues C, Derocher AE, Roth JD, McGeachy D, Pilfold NW.   +4 more
europepmc   +1 more source