Results 111 to 120 of about 1,624,308 (352)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Environmental and anthropogenic drivers of watercress (Nasturtium officinale) communities in char-lands and water channels across the Swat River Basin: implication for conservation planning [PDF]

open access: gold, 2023
Nasrullah Khan   +7 more
openalex   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

A multifunctional synergy development evaluation model of the impact of the cascade reservoir construction sequence on basins

open access: yesEcological Indicators
Considering the mass reservoirs construction, it is important to study the cascade reservoir construction sequence, which directly affects the water and sediment resource allocation, ecological environment restoration, and socioeconomic development of ...
Wanjie Zhao   +6 more
doaj   +1 more source

Evaluating Drought Vulnerability of Small Community Surface Water Supply Systems in the Midwest [PDF]

open access: yes, 2009
This report presents approaches and data availability for evaluating the drought vulnerability of small community water supply systems in the Midwest that obtain water from surface water bodies, such as rivers, streams, natural lakes, and man-made ...
Hecht, Jory S., Knapp, H. Vernon
core  

Finite Blocklength Rates over a Fading Channel with CSIT and CSIR

open access: yes, 2017
In this work, we obtain lower and upper bounds on the maximal transmission rate at a given codeword length $n$, average probability of error $\epsilon$ and power constraint $\bar{P}$, over a finite valued, block fading additive white Gaussian noise (AWGN)
K, Deekshith P, Sharma, Vinod
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin   +2 more
wiley   +1 more source

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