Results 141 to 150 of about 2,321,749 (354)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Diatom based transfer function for estimating the chemical composition of fossil water. Calibration based on salt lakes of the Lipez area in the southwestern Bolivian Altiplano.

Carnets de Géologie, 2002
Diatom assemblages and water chemistry were studied in 13 shallow salt lakes in the southern part of the Bolivian Altiplano. At each locality bottom sediment and water samples were collected simultaneously.
Roux Maurice, Risacher François, Servant-Vildary Simone   +2 more
doaj  

Soil Column Experimental Study on the Effect of Soil Structure Disturbance on Water Chemistry. [PDF]

Int J Environ Res Public Health, 2022
Long Y, Huang T, Zhang F, Zhao Y.
europepmc   +1 more source

MSATT Workshop on Chemical Weathering on Mars [PDF]

The topics covered with respect to chemical weathering on Mars include the following: Mars soil, mineralogy, spectroscopic analysis, clays, silicates, oxidation, iron oxides, water, chemical reactions, geochemistry, minerals, Mars atmosphere, atmospheric
Banin, Amos, Burns, Roger
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Detection, fate and transport of the biohazardous agent Toxoplasma gondii in soil water systems: Influence of soil physicochemical properties, water chemistry and surfactant. [PDF]

Environ Microbiol Rep, 2023
Kinsey EN, Korte C, Gouasmia S, L'Ollivier C, Dubey JP, Dumètre A, Darnault CJG.   +6 more
europepmc   +1 more source

Phytoplanktonic Structure and Chemistry of the Water in the Monjolinho Reservoir (SP, Brazil) During a Cyanobacterial Bloom Episode

, 2010
Rosana B. Sotero-Santos, Maria José Dellamano-Oliveira, Elisa Garcia Carvalho, Alessandro Minillo, Odete Rocha   +4 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Corrigendum: Chiral water-soluble molecular capsules with amphiphilic interiors

Frontiers in Chemistry, 2023
Arkadiusz Marek Sakowicz, Agnieszka Szumna   +1 more
doaj   +1 more source